Chloroquininephosphate

CAS 1446-17-9 MFCD N/A

化学结构图

1446-17-9
SMILES: C=C[C@@H]1CN2CC[C@@H]1C[C@@H]2[C@@H](OCl)c1ccnc2ccc(OC)cc12.O=P(O)(O)O

化学属性

Mol. Weight417.92
Mol. FormulaC18H26ClN3.H3O4P

别名和识别编码

Chemical NameQuinoline,7-chloro-4((4-(diethylamino)-1-methylbutyl)amino)-,phosphate (1:1)
Chemicalbook IDCB91246727
Wiswesser Line NotationT66 BNJ EMY1&3N2&2 IG &P-O4
Synonym Chloroquine, phosphate Araten phosphate
CAS Number1446-17-9
PubChem Substance ID83818
InChIInChI=1S/C18H26ClN3.H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H3,1,2,3,4)
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安全信息

RTECSVB2625000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 27,95,1961

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   JFSCAS Journal of Forensic Sciences.  (American Soc. for Testing and
   Materials, 1916 Race St., Philadelphia, PA 19103)  V.1-    1956-
   Volume(issue)/page/year: 5,201,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2740 mg/kg/39W
TOXIC EFFECTS :
   Behavioral - muscle weakness
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 93,209,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPT

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : female 18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 31,173,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 2660 mg/kg
SEX/DURATION            : female 2-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   AROTAA Archives of Otolaryngology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.1-52, 1925-50; V.72-    1960-  Volume(issue)/page/year:
   80,407,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 420 mg/kg
SEX/DURATION            : female 1-6 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AROTAA Archives of Otolaryngology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.1-52, 1925-50; V.72-    1960-  Volume(issue)/page/year:
   80,407,1964

TYPE OF TEST

系列性分类

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