Oxymetazoline 羟甲唑啉

CAS 1491-59-4 MFCD00242798

化学结构图

1491-59-4
SMILES: Cc1cc(C(C)(C)C)c(O)c(C)c1CC1=NCCN1

化学属性

Mol. FormulaC16H24N2O
Mol. Weight260.42
Melting Point182 ºC

别名和识别编码

Chemical NameOxymetazoline
EC Number216-079-1
Synonym 2-(3-Hydroxy-2,6-dimethyl-4-tert-butylbenzyl)-2-imidazoline; 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol 2-(3-羟基-2,6-二甲基-4-叔丁基苄基)-2-咪唑啉 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-pheno 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-pheno 6-叔丁基-3-(4,5-二氢-1H-咪唑-2-基甲基)-2,4-二甲基苯酚 H-990 Hazol Hydrochloride, Oxymetazoline Iliadin Nafrine Nasivine Navasin Oxy
CAS Number1491-59-4
MDL NumberMFCD00242798
Chemical Name Translation羟甲唑啉
Wiswesser Line NotationT5M CN BUTJ B1R CQ B1 F1 DX1&1&1
Beilstein Registry Number0886303
LabNetwork Molecule IDLN01344155
PubChem Substance ID4636
InChIInChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
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安全信息

Packing GroupII
Hazard Class6.1(a)
UN Number 3249
Restrict 剧毒化学品
RTECSSK1050000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2700 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 1,74,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 11,563,1975

Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H318 Causes serious eye damage 严重伤害眼睛
  • H330 Fatal if inhaled 吸入致命
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P316
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P316
  • P317
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • MOL 文件:1491-59-4.mol
  • MSDS 信息:Oxymetazoline(1491-59-4).msds

系列性分类


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