[2-(4-Chlorophenyl)-1,1-dimethylethyl]amine hydrochloride

CAS 151-06-4 MFCD01708326

化学结构图

151-06-4
SMILES: CC(C)(N)Cc1ccc(Cl)cc1.Cl

化学属性

Mol. FormulaC10H15Cl2N
Mol. Weight220

别名和识别编码

Chemical NamePhenethylamine, p-chloro-alpha,alpha-dimethyl-,hydrochloride
CAS Number151-06-4
Alfabeta NameCHLOROPHENYLDIMETHYLETHYLAMINEHYDROCHLORIDE 2411[]()----,
MDL NumberMFCD01708326
Synonym NSC-76098 Avicol Lucofen ######## W 2426 Lucofene Pre-Sate S 62-2 S-62 4-Chloro-alpha,alpha-dimethylphenethylamine hydrochloride Chlorphentermine hydrochloride Chlorophentermine hydrochloride 1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride alpha,alpha-Dimethyl-p-chlorophenethylamine hydrochloride p-Chloro-alpha,alpha-dimethylphenethylamine hydrochloride Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-, hydrochloride Presate hydrochloride
Wiswesser Line NotationZX1&1&1R DG &GH
Chemical Name Translation
LabNetwork Molecule IDLN00161291
PubChem Substance ID65477
InChIInChI=1S/C10H14ClN.ClH/c1-10(2,12)7-8-3-5-9(11)6-4-8;/h3-6H,7,12H2,1-2H3;1H
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分类

  • Amines
  • Aromatics
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

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相关文献及参考

  • Gylys, J.A. et al.: J. Pharmacol. Exp. Therap., 137, 365 (1962); Jun, H.W. et al.: Can. J. Pharmac. Sci., 4, 27 (1969); Luellmann, H. et al.: J. Pharm. Pharmacol., 25, 239 (1973);

安全信息

Warnings IRRITANT
RTECSSH1225000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Skin and Appendages - hair
REFERENCE :
   APSXAS Acta Pharmaceutica Suecica.  (Apotekarsocieteten-Farmacevtiska
   Foereningen, Box 1136, S-111, 81 Stockholm, Sweden)  V.1-    1964-
   Volume(issue)/page/year: 4,37,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 144 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   17,121,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 137,365,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   CHTPBA Chimica Therapeutica.  (Paris, France)  V.1-8, 1965-73.  For
   publisher information, see EJMCA5.  Volume(issue)/page/year: 5,247,1970

TYPE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 16-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 1,31,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 16-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   EXMPA6 Experimental and Molecular Pathology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1962-  Volume(issue)/page/year:
   38,310,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE                    : 21 mg/kg
SEX/DURATION            : female 32-68 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.1-    1968-
   Volume(issue)/page/year: 39,59,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 27 mg/kg
SEX/DURATION            : female 12-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   VAAZA2 Virchows Archiv,

系列性分类

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