9-Fluoro-16α,17-(isopropylidenedioxy) Corticosterone (6As,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-氟-7-羟基-8b-(2-羟基乙酰基)-6a,8a,10,10-四甲基-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-十二氢-1H-萘酚[2',1:4,5]茚并[1,2-d][1,3]二氧基-4(2H)-酮 （曲安奈德杂质）
CAS 1524-86-3 MFCD09263628
化学结构图
SMILES: CC1(C)OC2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)C2(C(=O)CO)O1
化学属性
| Mol. Formula | C24H33FO6 |
|---|---|
| Mol. Weight | 436.51 |
| Melting Point | 249-254 °C |
别名和识别编码
| Chemical Name | 9-Fluoro-16α,17-(isopropylidenedioxy) Corticosterone |
|---|---|
| CAS Number | 1524-86-3 |
| Synonym | (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one (Triamcinolone Acetonide Impurity ) {LY} (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one (Triamcinolone Acetonide Impurity ) {} {LY} (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one (Triamcinolone Acetonide Impurity ) {} {} {LY} (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one (Triamcinolone Acetonide Impurity ) {} {} |
| EC Number | 216-195-2 |
| Chemical Name Translation | (6As,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-氟-7-羟基-8b-(2-羟基乙酰基)-6a,8a,10,10-四甲基-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-十二氢-1H-萘酚[2',1:4,5]茚并[1,2-d][1,3]二氧基-4(2H)-酮 （曲安奈德杂质） |
| PubChem Substance ID | 228786 |
| InChI | InChI=1S/C24H33FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h9,15-17,19,26,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 |
| Canonical SMILES | OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C(CC4)=CC(CC5)=O)C)F)([H])C[C@@]1([H])OC(C)(O2)C)C)=O |
| MDL Number | MFCD09263628 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Steroids
产品应用
- Synthetic fluorinated corticosteroid tested for inhibition of granuloma in rats and for vasoconstriction activity in human subjects; potential topical antiinflammatory agent.
相关文献及参考
- Hannah, J. et al.: J. Med. Chem., 18, 168 (1975);
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