Paramethasone acetate 帕拉米松乙酸酯

CAS 1597-82-6 MFCD00200359

化学结构图

1597-82-6
SMILES: CC(=O)OCC(=O)C1(O)C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3C(O)CC21C

化学属性

Mol. FormulaC24H31FO6
Mol. Weight435

别名和识别编码

Chemical NameParamethasone acetate
Chemical Name Translation帕拉米松乙酸酯
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ G1 LF
Synonym 16-alpha-Methyl-6-alpha-fluoro-prednisolone-21-acetate 21-Acetyl-6-alpha-fluoro-16-alpha-methylprednisolone 6-alpha-Fluoro-16-alpha-methylprednisolone 21-acetate Alondra Cortidene Dilar Haldrate Haldrone Monocortin Paramethasone 21-acetate Paramethasone acetate Sintecort paramethasone acetate
CAS Number1597-82-6
PubChem Substance ID443928
InChIInChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21-,22+,23+,24+/m1/s1
MDL Number
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安全信息

RTECSTU4025000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 392 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,588,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10500 ug/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NFGZAD Nippon Funin Gakkai Zasshi.  Japanese Journal of Fertility and
   Sterility.  (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku,
   Toyko 162, Japan)  V.1-    1956-  Volume(issue)/page/year: 13,211,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2625 ug/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   NFGZAD Nippon Funin Gakkai Zasshi.  Japanese Journal of Fertility and
   Sterility.  (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku,
   Toyko 162, Japan)  V.1-    1956-  Volume(issue)/page/year: 13,211,1968

Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P318
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类


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