Hexamethylphosphorous Triamide 三(二甲胺基)膦

CAS 1608-26-0 MFCD00008301

化学结构图

1608-26-0
SMILES: CN(C)P(N(C)C)N(C)C

化学属性

Mol. FormulaC6H18N3P
Mol. Weight163.20
Density0.898 g/mL at 25 °C(lit.)
Refractive index1.4640 to 1.4670
Boiling Point163°C
Flash Point26°C(lit.)
TSCAYes
Melting Point-44°C
Solubility起反应
Stability对空气敏感;热和湿度敏感
Appearance 无色吸湿性液体。沸点162-164℃，49-51℃（1.6kPa）。溶于水、醇、醚、苯。

别名和识别编码

Chemical NameHexamethylphosphorous Triamide
CAS Number1608-26-0
Synonym N,N,N',N',N'',N''-Hexamethylphosphinetriamine {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hexamethylphosphinetriamine {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N,N',N',N'',N''-Hex
MDL NumberMFCD00008301
EC Number216-534-4
Beilstein Registry Number4(4)274
PubChem Substance ID87577088
Reaxys-RN906778
Chemical Name Translation三(二甲胺基)膦
LabNetwork Molecule IDLN00226609
InChIInChI=1S/C6H18N3P/c1-7(2)10(8(3)4)9(5)6/h1-6H3
Canonical SMILESCN(C)P(N(C)C)N(C)C
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分类

  • {SNA} Catalysis and Inorganic Chemistry, Chemical Synthesis, Phosphine Compounds, Phosphine Ligands
  • Phosphorylating and Phosphitylating Agents
  • {uni_hamburg} no charge; 1fragment
  • Miscellaneous Reagents

产品应用

  • Reagent combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations.

相关文献及参考

  • Has also been used for a variety of other reductions including that of ozonolysis intermediates: Helv. Chim. Acta, 50, 2387 (1967), and of primary alkyl nitro compounds to nitriles: Synthesis, 36 (1979). Bromohydrins can be converted to alkenes, by reductive elimination from their triflate esters: J. Am. Chem. Soc., 102, 1433 (1980):
  • Reacts with BrCCl3 to give dichloromethylenephosphorane Cl2C=PPh3, which undergoes Wittig reaction with aldehydes to give 1,1-dichloroalkenes, giving better results than the CCl4/PPh3 combination: Tetrahedron Lett., 1237, 1239 (1977); Synthesis, 554 (1980). Similarly, with Br2CF2, the CF2 group can be transferred to both aldehydes and ketones: J. Fluorine Chem., 1, 123 (1971); Synth. Commun., 3, 197 (1973).
  • Reduces aromatic aldehydes to symmetrical epoxides in good yield: J. Am. Chem. Soc., 85, 1884 (1963). Both cis- and trans-isomers are formed. For list of examples, see: Org. Synth. Coll., 5, 358 (1973). Under suitable conditions, reaction of the intermediate with a second aldehyde can lead to mixed deoxybenzoins or diaryl enamines: Synthesis, 225 (1991).
  • Ryu, H., et al.: J. Mat. Sci., 41, 8265 (2006),
  • Short: II/2
  • Short: II/25D

安全信息

Signal word Danger Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R45 May cause cancer 可能致癌
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R46 May cause inheritable genetic damage 可能引起遗传基因损害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R10 Flammable 易燃
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P312+P362+P364
  • P303+P361+P353
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P332+P313
  • P337+P313
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H350 May cause cancer 可能致癌
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
RTECSTH3390000
Packing GroupIII
UN Number 1993 UN 1993 3/PG 3 UN1993
Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen 0-10 0-10°C Air Sensitive Store at RT. {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {L
Hazard Codes T T,Xi,Xn Xn
Hazard Class3 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 212,193,1989

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   38,418,1978

其他信息

  • TCI Shanghai:三(二甲胺基)膦(可能有沉淀物) Tris(dimethylamino)phosphine (may contain precipitate),>;95.0%(GC)(1608-26-0)
  • 上游原料:氢氧化钠 --> 盐酸 --> 乙醚 --> 四氢呋喃 --> 正己烷 --> 氢化铝锂 --> 三氯化磷 --> 二甲胺 --> 环己烷 --> N,N-二甲基三甲基硅胺
  • 下游产品:N-二甲基-1，1-螺旋茚丹-7，7-二基磷铵 --> N-二甲基-[(S)-1,1'-螺二氢茚-7,7'-二基]亚磷酰胺
  • Acros Organics:六甲基磷酰三胺 Hexamethylphosphorous triamide, 97%(1608-26-0)
  • Hazard Note:Irritant
  • 用途一:有机合成中间体。
  • 检测方法:PNMR,NMR
  • Alfa Aesar:己甲基亚磷三酰胺,97% Hexamethylphosphorous triamide, 97%(1608-26-0)
  • MOL 文件:1608-26-0.mol
  • 海关编码:29299000
  • 方法一:将137.3g（1.0mol）三氯化磷溶于1.5L无水乙醚，搅拌，冷至1-5℃，通入过量的无水二甲胺气体，控制通气速度，使反应温度不超过15℃，通气毕，在氮氛中于室温放置过夜，滤除二甲胺盐酸盐，滤液减压蒸发回收乙醚，得152-154g，油状的六甲基亚磷酰三胺，收率94-95%。
  • Sigma Aldrich:1608-26-0(sigmaaldrich)
  • F:10
  • MSDS 信息:Tris(dimethylamino)phosphine(1608-26-0).msds
  • 存储注意事项:氮气保护
  • 图谱信息:三(二甲胺基)膦(1608-26-0)核磁图( 13 CNMR) 三(二甲胺基)膦(1608-26-0)核磁图( 1 HNMR) 三(二甲胺基)膦(1608-26-0)红外图谱(IR1) 三(二甲胺基)膦(1608-26-0)质谱(MS)
  • 敏感性:Moisture Sensitive
  • 三(二甲胺基)膦价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1317 三(二甲氨基)膦(可能有沉淀物) Tris(dimethylamino)phosphine (may contain precipitate) 250ML 6150元 2014/06/02 T1317 三(二甲氨基)膦(可能有沉淀物) Tris(dimethylamino)phosphine (may contain precipitate) 25ML 1060元 2010/06/21 162480500 三(二甲胺基)膦 Hexamethylphosphorous triamide 97% 50 ML 3257元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds Catalysis 磷化合物催化剂
  4. Phosphine Ligands 膦配体
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. Phosphorus Compounds
  4. Elemental Phosphorus
  1. Phosphine
  2. Phosphorus
  1. Ligands
  2. Phosphorus

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