5'-Deoxy-5'-(methylthio)adenosine 5’-S-甲基-5’-硫代腺苷

CAS 2457-80-9 MFCD00010533

化学结构图

2457-80-9
SMILES: CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

化学属性

Mol. FormulaC11H15N5O3S
Mol. Weight297.33
Density1.422
Melting Point210-213 °C
Boiling Point642.7±65.0 °C at 760 mmHg

别名和识别编码

Chemical Name5'-Deoxy-5'-(methylthio)adenosine
CAS Number2457-80-9
Synonym 5'-Methylthioadenosine {LY} 5'-Methylthioadenosine {} {LY} 5'-Methylthioadenosine {} {} {LY} 5'-Methylthioadenosine {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylthioadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5'-Methylt
MDL NumberMFCD00010533
PubChem Substance ID439176
Beilstein Registry Number42420
EC Number250-023-7
Chemical Name Translation5’-S-甲基-5’-硫代腺苷
LabNetwork Molecule IDLN00197104
InChIInChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
Canonical SMILESNC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSC)O3
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分类

  • {SNA} Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, D-DIF, Epigenetics, Histone Methylation Modulators, Molecular Biology, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides, Protein Arginine Methyltransferase (PRMT) Modulators
  • {S
  • {SNA} Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, D-DIF, Histone Methylation Modulators, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides, Protein Arginine Methyltransferase (PRMT) Modulators, 分子生物学, 生物活性小分子, 细胞生物学, 表观遗传学
  • {SNA} Bioactive Small Molecules,

产品应用

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相关文献及参考

  • A. I. Longshaw, et al., Design and Synthesis of Potent "Sulfur-Free" Transition State Analogue Inhibitors of 5'-Methylthioadenosine Nucleosidase and 5'-Methylthioadenosine Phosphorylase J. Med. Chem. 53 , 6730-6746, (2010) 摘要
  • Basu I, Locker J, Cassera MB, et al., Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase. J. Biol. Chem. 286 , 4902-4911, (2011) 摘要
  • Beil. 26 ,IV,3675
  • Bertino JR, Waud WR, Parker WB, Lubin M., Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies. Cancer Biol. Ther. 11 , 627-632, (2011) 摘要
  • Chung J, Goo E, Yu S, et al., Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase. Proc. Natl. Acad. Sci. U. S. A. 108 , 12089-12094, (2011) 摘要
  • Garcia-Manteiga JM, Mari S, et al., Metabolomics of B to plasma cell differentiation. J. Proteome Res. 10 , 4165-417

安全信息

WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSAU7410000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-46124

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 8,653,1987

Storage condition -20°C, protect from light {LY} -20°C, protect from light {} {LY} -20°C, protect from light {} {} {LY} -20°C, protect from light {} {} {} {LY} -20°C, protect from light {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Epigenetics - Molecular Biology
  4. Bioactive Small Molecules for Epigenetic Research - Epigenetics
  5. Histone Methylation Modulators - Bioactive Small Molecules for Epigenetic Research
  6. Protein Arginine Methyltransferase (PRMT) Modulators - Histone Methylation Modulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Deoxynucleosides&Deoxynucleotides and their Analogs
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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