Cyclofenil 环芬尼

CAS 2624-43-3 MFCD00190153

化学结构图

2624-43-3
SMILES: CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1

化学属性

Mol. FormulaC23H24O4
Mol. Weight364.47
Appearance solid
SolubilitySoluble in DMSO: ≥10 mg/mL,

别名和识别编码

Chemical NameCyclofenil
CAS Number2624-43-3
Synonym ######## (Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate 4,4′-Cyclohexylidenemethylenediphenol 4,4'-CYCLOHEXYLIDENEMETHYLENEDIPHENOL DIACETATE 4-((4-(Acetyloxy)phenyl)cyclohexylidenemethyl)phenol Acetate 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate 4-(CYCLOHEXYLIDENEMETHYLENE)-BIS-PHENOL DIACETATE 4-(Cyclohexylidenemethylene)-bis-phenol Bis-(p-acetoxyphenyl)-cyclohexylidenemethane Bis-(p-hydroxyphenyl)-cyclohexylidenemethane diacetate CYCLOFENIL Cyclofenil Cyclofenyl Cyclopenil Cyclophenil Cyclophenyl F 6066 F-6066 F6066 Fertodur; (Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate; [4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate H 3452 ICI 48213 Oginex
MDL NumberMFCD00190153
EC Number220-089-1
Chemical Name Translation环芬尼
Wiswesser Line NotationL6YTJ AUYR DQ&R DQ
Beilstein Registry Number2014687
LabNetwork Molecule IDLN00202493
PubChem Substance ID2898
InChIInChI=1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3
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分类

  • Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, Hormones, Steroid Hormones
  • {SNA} Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, Hormones, Steroid Hormones

产品应用

  • A selective estrogen receptor modulator

相关文献及参考

  • Miquel, et al.: J. Med. Chem., 6, 774 (1963),
  • Merck 14 ,2720

安全信息

WGK Germany2
RTECSGO7550000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 储存温度2-8℃ 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,313,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >12500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - anorexia (human)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   23,365,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,313,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 4,821,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   1,397,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 32 mg/kg
SEX/DURATION            : female 1-2 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   25,65,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 32 mg/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   25,65,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 3-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   APTSAI Acta Pharmacologica et Toxicologica, Supplementun.  (M

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352
  • P305+P351+P338
  • P308+P313
  • P318
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • MSDS 信息:[4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate(2624-43-3).msds
  • Cyclofenil is a non-steroidal selective estrogen receptor modulator (SERM). Cyclofenil shows a higher affinity for ERβ than ERα.
  • MOL 文件:2624-43-3.mol
  • Sigma Aldrich:2624-43-3(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Estrogen - Steroid Hormones

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