Acadesine AMP-激活的蛋白激酶（AMPK）激动剂类：例如阿卡地新(兴奋剂类，不能销售)

CAS 2627-69-2 MFCD00869751

化学结构图

2627-69-2
SMILES: NC(=O)c1ncn(C2OC(CO)C(O)C2O)c1N

化学属性

Mol. FormulaC9H14N4O5
Mol. Weight258.23
Melting Point214-215°C
Density1.422
Appearance powder
SolubilitySoluble in water (9 mg/ml), and DMSO (75 mM).
Boiling Point726.3°C at 760 mmHg

别名和识别编码

Chemical NameAcadesine
CAS Number2627-69-2
Synonym AICAR {LY} AICAR ARA 100 ARA-100 ARA100 Acadesine Acadesine, N1 Acadesine, N1-(-D-Ribofuranosyl)-5-aminoimidazole GP 1 110 Z-riboside acadesine aminoimidazole carboxamide ribonucleoside arasine {} {LY} AICAR {} {} {LY} AICAR {} {} {} {LY} AICAR {} {} {} {} {LY} AICAR {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} AICAR {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID17513
EC Number220-097-5
MDL NumberMFCD00869751
Beilstein Registry Number2384789
Chemical Name TranslationAMP-激活的蛋白激酶（AMPK）激动剂类：例如阿卡地新(兴奋剂类，不能销售)
InChIInChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
LabNetwork Molecule IDLN00194818
Canonical SMILESOC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N)=C(N=C2)C(N)=O)O1
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分类

  • {SNA} A-AM, AMP-Activated Protein Kinase (AMPK), Bioactive Small Molecules, Cancer Metabolism, Cell Biology, Cell Signaling and Neuroscience, Inhibitors and Activators of the AMPK pathway, Inhibitors of Aerobic Glycolysis (the Warburg Effect), Kinase/Phosphatase Biology, Serine/Threonine Kinase Activators,
  • {SNA} A-AM, AMP-Activated Protein Kinase (AMPK), AMPK通路抑制剂和激活剂, Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 有氧糖酵解（Warburg效应）, 有氧糖酵解（Warburg效应）抑制剂, 生物活性小分子, 癌症代谢, 癌症研究, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • An inhibitor of the transcription of PPARα, the coactivation of PPARα.

相关文献及参考

  • Mullane, K., et al.: Trends Cardiovasc Med., 3, 227 (1993),
  • Velásquez, D.A., et al., The Central Sirtuin 1/p53 Pathway Is Essential For The Orexigenic Action Of Ghrelin. Diabetes 60 , 1177-85, (2011) 摘要
  • Giri, S., et al., 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J. Neurosci. 24 , 479-487 , (2004)
  • Merck 14 ,16

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • Acadesine导致ZMP的积累，Acadesine模仿AMP对AMPK和AMPK的刺激作用。
  • Sigma Aldrich:2627-69-2(sigmaaldrich)
  • MOL 文件:2627-69-2.mol
  • color:tan

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Activators - Serine/Threonine Kinase Biology
  7. AMP-Activated Protein Kinase (AMPK) - Serine/Threonine Kinase Activators
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Activators - Serine/Threonine Kinase Biology
  7. AMP-Activated Protein Kinase (AMPK) - Serine/Threonine Kinase Activators
  1. Life Science 生命科学
  2. Cancer Research
  3. Cancer Metabolism - Cancer Research
  4. Aerobic Glycolysis (the Warburg Effect) - Cancer Metabolism
  5. Cancer Metabolism: Inhibitors of Aerobic Glycolysis
  6. Inhibitors and Activators of the AMPK pathway - Inhibitors of Aerobic Glycolysis (the Warburg Effect)

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