Piericidin A from microbial source Piericidin

CAS 2738-64-9 MFCD01677956

化学结构图

2738-64-9
SMILES: C[C@@H](/C=C(\C)/C/C=C/C(/C)=C/CC1N=C(OC)C(OC)=C(O)C=1C)[C@H](O)/C(/C)=C/C |&1:1,24|

化学属性

Mol. FormulaC25H37NO4
Mol. Weight416

别名和识别编码

Chemical NameA
Synonym 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R) 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R) 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl- Piericidin A1 SN 198E Shaoguamycin B 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl- Piericidin Piericidin A Piericidin A from microbial source Piericidin A1 Piericidin(sub 1) Piericidine A SN 198E Shaoguamycin B Shaoguanmycin B
MDL NumberMFCD01677956
PubChem Substance ID6437838
CAS Number2738-64-9
Chemical Name TranslationPiericidin
Wiswesser Line NotationT6NJ B2UY1&1U2Y1&U1Y1&YQY1&U2 C1 DQ EO1 FO1
Beilstein Registry Number1555726
InChIInChI=1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1
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分类

  • Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, P
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Signaling and Neuroscience, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, P, 细胞生物学
  • {SNA} Apoptosis and Cell Cyc
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, PI-PZ, 生物活性小分子, 细胞信号转导和神经科学,

相关文献及参考

  • Darrouzet, E., et al. FEBS Lett. 431 , 34, (1998)
  • Prieur, I., et al. Biochim. Biophys. Acta 1504 , 173, (2001)
  • Galkin, A.S., et al. FEBS Lett. 451 , 157, (1998) 摘要

安全信息

WGK Germany1
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Symbol
RTECSYD4588000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
Signal word Danger
Hazard Codes Xn
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3170 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 32,1115,1968

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 360 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 34,1101,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2520 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 32,1115,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 870 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 27,576,1963

TYPE OF TEST            : LDLo - Lowest published leth

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Mitochondrial Proteins, Antibodies, and Transport Inhibitors - Apoptosis and Cell Cycle
  6. Mitochondrial Transport Inhibitors - Mitochondrial Proteins, Antibodies, and Transport Inhibitors
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Mitochondrial Proteins, Antibodies, and Transport Inhibitors - Apoptosis and Cell Cycle
  6. Mitochondrial Transport Inhibitors - Mitochondrial Proteins, Antibodies, and Transport Inhibitors

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