(Z)-4-((1S,3Ar,5S,11R,14As)-8-Hydroxy-2,2,11-Trimethyl-13-(3-Methylbut-2-En-1-Yl)-11-(4-Methylpent-3-En-1-Yl)-4,7-Dioxo-1,2,5,7-Tetrahydro-11H-1,5-Methanofuro[3,2-G]Pyrano[3,2-B]Xanthen-3A(4H)-Yl)-2-Methylbut-2-Enoic Acid (Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-1,2,5,7-四氢-11H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a(4H)-基)-2-甲基丁-2-烯酸

CAS 2752-65-0 MFCD01714923

化学结构图

2752-65-0
SMILES: CC(C)=CCCC1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)OC12C(=CC4CC1C(C)(C)OC2(CC=C(C)C(=O)O)C4=O)C3=O

化学属性

Mol. FormulaC38H44O8
Mol. Weight629
Density1.29
Boiling Point280°C
Melting Point81.8°C

别名和识别编码

Chemical Name(Z)-4-((1S,3Ar,5S,11R,14As)-8-Hydroxy-2,2,11-Trimethyl-13-(3-Methylbut-2-En-1-Yl)-11-(4-Methylpent-3-En-1-Yl)-4,7-Dioxo-1,2,5,7-Tetrahydro-11H-1,5-Methanofuro[3,2-G]Pyrano[3,2-B]Xanthen-3A(4H)-Yl)-2-Methylbut-2-Enoic Acid
CAS Number2752-65-0
Synonym 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid B"-Guttiferrin Beta-Guttiferrin Beta-Guttilactone Cambogic acid Guttatic acid Guttic acid 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid B"-Guttiferrin Beta-Guttiferrin Beta-Guttilactone Cambogic acid Guttatic acid Guttic acid B''-Guttiferin Cambogic acid beta-Guttiferin 藤黄酸
Chemical Name Translation(Z)-4-((1S,3aR,5S,11R,14aS)-8-羟基-2,2,11-三甲基-13-(3-甲基丁-2-烯-1-基)-11-(4-甲基戊-3-烯-1-基)-4,7-二氧代-1,2,5,7-四氢-11H-1,5-甲桥呋喃并[3,2-g]吡喃并[3,2-b]氧杂蒽-3a(4H)-基)-2-甲基丁-2-烯酸
PubChem Substance ID9852185
LabNetwork Molecule IDLN01326450
InChIInChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1
MDL NumberMFCD01714923
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分类

  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, G, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,
  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Signaling and Neuroscience, G, Nutrition Research, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 细胞生物学
  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, G, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 营养研究

产品应用

  • 藤黄酸作为蛋白酶激活和凋亡诱导剂，会捕获细胞周期的G2 / M期，而且造成不可逆。

安全信息

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301 IF SWALLOWED: 如果吞下去
  • P305 IF IN EYES: 如果进入眼睛
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P338 Remove contact lenses, if present and easy to do. Continue rinsing. 如果戴隐形眼睛并容易摘掉的话，取出隐形眼镜，继续冲洗。
  • P351 Rinse cautiously with water for several minutes. 小心地用水冲洗几分钟。
RTECSPB9268200
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany1
Signal word Danger
Hazard Codes 6.1 T
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 储存温度-20°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 88 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 5,96,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 107 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 5,96,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai
   Science/Technology Publisher, Peop. Rep. China, 1994
   Volume(issue)/page/year: -,220,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 354 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(1),331,1982

UN Number 2811
Packing GroupIII

其他信息

  • 不溶于水

系列性分类

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