Parathion-methyl 甲基对硫磷

CAS 298-00-0 MFCD00041813

化学结构图

298-00-0
SMILES: COP(=S)(OC)Oc1ccc([N+](=O)[O-])cc1

化学属性

Mol. FormulaC8H10NO5PS
Mol. Weight263.22
Flash Point46.1 ºC
Melting Point36 ºC
Boiling Point143 ºC (1.0 MMHG)
Density1.36
Solubility0.005 G/100 ML
Stability对光线敏感

别名和识别编码

Chemical NameParathion-methyl solution
Synonym {uni_hamburg} Dimethyl p-nitrophenyl phosphorothionate 甲基对硫磷粉剂 { Metacid MPT(R) O,O-二甲基-O-(4-硝基苯基)硫代磷酸酯 M-Parathion Phosphorothioic a NITRAN BAY 11405 METHYL PARATHION Folidol M 50 Azophos Thiophenit Bladan-M O,O-DIMETHYL-O-P-NITROPHENYL PHOSPHOROTHIOATE(R) M-Parath O,O-Dimethyl-O-p-nitrofenylester kyseliny thiofosforecne O,O-dimethyl O-(4-nitrophenyl) phosphorothioate Oleovofotox Dimethyl 4-nitrophenyl phosphorothioate METACIDE 硫代磷酸-O,O-二甲基-O-对硝基苯基酯 {uni_hambur Vofatox Fosferno M 50 Metafos ME 1605 Methylparathion Metacide Yphos {uni_ham {uni_hamburg DIMETHY O,O-dimethyl O-(4-nitrophenyl)phosphorothioate Probel MP 2 METACIDE(R) dimethyl 4- Folidol M Dimethyl p-nitrophenyl monothiophosphate 8056HC {uni {C PARATHION-METHYL Metacid 50 Vof Wofatox BAY E-601 Folidol M 40 {uni_ha O,O-Dimethyl O-(p-nitrophenyl) phosphorothioate Phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl) ester phosphorothioic acid, O,O-dimethyl O-(p-nitrophenyl) ester {un FOLIDOL-M(R) O,O-Dimethyl O-(p-nitrophenyl) thiophos NCI-C0297 CEKUMETHION p-Nitrophenyldimethylthionophosphate Thylpar M-50 Parataf O,O-Dimethyl-O-(4-nitrophenyl) phosphorothioate
MDL NumberMFCD00041813
PubChem Substance ID4130
Beilstein Registry Number1914724
CAS Number298-00-0
EC Number206-050-1
Chemical Name Translation甲基对硫磷
Wiswesser Line NotationWNR B1 DOPS&O1&O1
InChIInChI=1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3
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分类

  • 2000/60/EC, Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, EPA, Endocrine Disruptors (Draft), Environmental Standards, European Community: ISO, DIN and DL 152, Insecticides, Metabolites, Method Specific, N-P, Oeko-Tex Standard 100, Organophorous, P, PA - PEN, Paraoxon-methyl metabolites, Pesticides, Pesticides & Metabolites
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SA} 2000/60/EC, Acaricides, Alpha sort,

产品应用

  • 校准仪器和装置;评价方法;工作标准;质量保证/质量控制;其他。

相关文献及参考

  • Short: EINECS
  • Short: IV/8A
  • Short: III/10a
  • Merck: 14,6108

安全信息

RTECSTG0175000
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H300 Fatal if swallowed 吞食致命
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Hazard Codes F,Xn,N T+;N,N,T+,Xn,F T+;N
WGK Germany2
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
Risk Statements
  • R5 Heating may cause an explosion 加热会引起爆炸
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
  • R48/22
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
  • R38 Irritating to skin 刺激皮肤
  • R36 Irritating to eyes 刺激眼睛
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R50/53
  • R51/53
UN Number UN 2052/2783/2811 2052/2783/2811
Packing GroupII
Hazard Class6.1(a)
Storage condition APPROX 4°C 避光、低温(<5˚C)、干燥处储存。 储存温度2-8℃
Restrict 剧毒化学品
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCBPBS Pesticide Biochemistry and Physiology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1971-  Volume(issue)/page/year:
   8,302,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APCRAW Advances in Pest Control Research.  (New York, NY)  V.1-18, 1957-68.
   Volume(issue)/page/year: 4,117,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 11,11,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the
   United States.  (Denver, CO)  V.3-38, 1939-74.  Volume(issue)/page/year:
   16,3,1952

TYPE OF TEST

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-138973

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 88,307,1981

{h

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 155,131,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 1

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 6 ug/L
REFERENCE :

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 114 mmol/L
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   10,161,1974

{hazar

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 60 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   15,609,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   JEBIDP Journal of Environmental Biology.  (Academy of Environmental Biology,
   India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1-   
   1980-  Volume(issue)/page/year: 17,51,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 44 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   AMSHAR Ac

其他信息

  • 灭火剂:水、泡沫、砂土、二氧化碳
  • 用途二:用
  • Sigma Aldrich:298-00-0(sigmaaldrich)
  • 产品特性:甲基对硫磷(Methyl parathion)属高毒杀虫剂。工业品为棕色或黄色液体或固体,纯品大鼠急性经口LD50为61-67毫克/千克,急性吸入LC50为120微克/立方米 (4升),大鼠急性无作用剂量为5毫克/千克,狗经口无作用剂量为0.1毫克/千克/天。其作用机制及杀虫谱与对硫磷相似。但该药的药效比对硫磷低,且残效短,对人、畜的毒性也较低,但它仍属高毒农药。 甲基对硫磷微化学品名称为O,O-二甲基-O-(4-硝基苯基)硫逐磷酸酯,易溶于石油醚,易溶于脂肪族和芳香族的卤素化合物中,难溶于水及石油,在中性或弱酸性介质中较稳定,常温下贮存一年,有效成分含量无显著变化。具触杀和胃毒作用,能抑制害虫神经系统中胆碱酯酶的活力而致死,杀虫谱广,常加工成乳油或粉剂(见农药剂型)使用,主要用
  • 注意事项:[1]不能
  • MSDS 信息:甲基对硫磷(298-00-0).ms
  • 方法一:由O,O-二甲基硫化磷酰氯在溶剂中与对硝基苯酚缩合而得。将二甲苯和对硝基酚钠在96℃(73.3-76.0kPa)以下共沸脱水2-3h,加入碳酸钠和铜粉,升温至90℃左右,滴加O,O-二甲基硫代磷酰氯。加毕,搅拌保温2-3h。冷却至50℃,过滤,用少量二甲苯冲洗滤渣,滤液用5%碳酸钠溶液洗至无色,再用饱和食盐水洗至中性,分出油层,减压蒸出二甲苯,即得甲基对硫磷原油。原药为浅黄色至浅棕色液体或固体。原料消耗定额:黄磷210kg/t、氯气690kg/t、硫黄200kg/t、甲醇600kg/t、对硝基酚钠730kg/t。
  • 用途四:该品为有机磷杀虫剂,具触杀和胃毒作用,能抑制害虫神经系统中胆碱酯酶的活力而使其致死,杀虫谱广,常加工成乳油或粉剂使用,防治对象与对硫磷(一六○五)相似,能防治水稻、棉花、果树、茶叶、蔬菜等作物的多种害虫。但防治效果稍低于对硫磷,因此用量要增加。由于甲基对硫磷比对硫磷安全,常用于防治棉花、果树的害虫。
  • 用途二:用作有机磷杀虫剂,主要用于防治水稻二化螟、三化螟、兼治飞虱、叶蝉、蓟马、稻苞虫、稻纵卷叶螟等水稻害虫
  • 毒性分级:剧毒
  • 用途三:有机磷杀虫剂,用于防治水稻、棉花、果树、茶叶、蔬菜等害虫
  • 急救治疗:[1]用阿托品1~5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4-1.2g 静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。
  • 使用方法:1.棉花害虫的防治 棉红蜘蛛、棉蛉虫、红蛉虫用甲基对硫磷乳油1500-2500倍液(每亩有效成份15-25克)喷雾。此剂量可防治棉蚜、棉蓟马、棉盲蝽。 2.水稻害虫的防治 三化螟每亩用50%乳油50-75毫升,对水50-75 千克喷雾。 稻纵卷叶螟、稻叶螟、 稻飞虱、稻蓟马每亩用50%乳油50-75毫升,对水5
  • 可燃性危险特性:遇明火、高热可燃; 受热产生有毒氮氧化物,磷氧化物和硫氧化物烟雾
  • 中毒症状:急性中毒多在12小时内发病,口服立即发病。轻度:头痛、头昏、恶心、呕 吐、多汗、无力、胸闷、视力模糊、胃口不佳等,全血胆碱酯酶活力一般降 至正常值的70-50%。中度:除上述症状外还出现轻度呼吸困难、肌肉震颤、瞳孔缩小、精神恍惚、行走不稳、大汗、流涎、腹疼、腹泻。重者还会出 现昏迷、抽搐、呼吸困难、口吐白沫、大小便失禁,惊厥,呼吸麻痹。
  • MOL 文件:298-00-0.mol
  • {C
  • 外观性质:无色结晶粉末,工业品为棕色或黄色液体或固体。
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类、食品添加剂分开存放
  • 上游原料:甲醇 --> 甲苯 --> 三氯氧磷 --> 碳酸钠 --> 三乙胺 --> 氯化钠 --> 氯 --> 硫磺 --> 铜 --> 五硫化二磷 --> 乳化剂 --> 三甲胺 --> 硫磺 --> 二甲基硫 --> 硫代磷酰氯 --> 黄磷 --> 石
  • 类别:农药

系列性分类


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