N-Acetyl-D-sphingosine N-乙酰基-D-鞘氨醇
CAS 3102-57-6 MFCD00153903
化学结构图
SMILES: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(C)=O
化学属性
| Mol. Formula | C₂₀H₃₉NO₃ |
|---|---|
| Mol. Weight | 341.53 |
| TSCA | No |
| Melting Point | 87-89°C |
| Boiling Point |
别名和识别编码
| Chemical Name | N-Acetyl-D-sphingosine |
|---|---|
| CAS Number | 3102-57-6 |
| Synonym | (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol N-Acetoyl-D-erythro-sphingosine Acetyl ceramide C2 Ceramide (d18:1/2:0) C2 ceramide Acetyl Ceramide Acetyl ceramide C2 Ceramide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | MFCD00153903 |
| PubChem Substance ID | 24891187 |
| Chemical Name Translation | N-乙酰基-D-鞘氨醇 |
| InChIKey | BLTCBVOJNNKFKC-QUDYQQOWSA-N |
| LabNetwork Molecule ID | LN01268993 |
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分类
- {SNA} A-AM,
- {SNA} A-AM, Anti-Proliferative Agents, Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Ceramides,
- A-AM, Anti-Proliferative Agents, Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Ceramides, Lipids, Lipids in Cell Signaling, Metabolic Pathways, Metabolomics, N-acylsphingosines (ceramides), Sphingolipid Metabolism, Sphingolipids
- {SNA} A-AM,
产品应用
- A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates pr
相关文献及参考
- [2]. Ji-Youn Kim, et al. Role of Protein Phosphatase 1 in Angiogenesis and Odontoblastic Differentiation of Human Dental Pulp Cells. J Endod. 2017 Mar;43(3):417-424.
- [3]. R T Dobrowsky, et al. Ceramide Stimulates a Cytosolic Protein Phosphatase. J Biol Chem. 1992 Mar 15;267(8):5048-51.
- [4]. R T Dobrowsky, et al. Ceramide Activates Heterotrimeric Protein Phosphatase 2A. J Biol Chem. 1993 Jul 25;268(21):15523-30.
- [5]. Maria Bernadete Riemma Pierre, et al. Influence of ceramide 2 on in vitro skin permeation and retention of 5-ALA and its ester derivatives, for Photodynamic Therapy. Brazilian Journal of Pharmaceutical Sciences. 2009, 45(1), 109-116.
- Didion, S.P. and Faraci, F.M., Ceramide-induced impairment of endothelial function is prevented by CuZn superoxide dismutase overexpression Arterioscler. Thromb. Vasc. Biol. 25 , 90-5, (2005)
- Dobrowsky, R.T. and Hannun, Y.A., Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Che
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S22 Do not breathe dust 不要吸入粉尘；
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