4’-Fluoro-[1,1’-Biphenyl]-4-Amine 4’-氟-[1,1’-联苯]-4-胺

CAS 324-93-6 MFCD00025338

化学结构图

324-93-6
SMILES: Nc1ccc(-c2ccc(F)cc2)cc1

化学属性

Mol. FormulaC12H10FN
Mol. Weight187.21
Melting Point119-121°C

别名和识别编码

Chemical Name4’-Fluoro-[1,1’-Biphenyl]-4-Amine
CAS Number324-93-6
Alfabeta NameFLUOROBIPHENYLYLAMINE 44----'
MDL NumberMFCD00025338
Synonym 4'-Fluoro-4-aminodiphenyl 4'-Fluoro-4-biphenylamine 4-(4-Fluorophenyl)aniline 4-(p-Fluorophenyl)aniline 4-AMINO-4'-FLUOROBIPHENYL 4-Amino-4'-fluorbifenyl 4-Amino-4'-fluorodiphenyl
EC Number206-306-2
Chemical Name Translation4’-氟-[1,1’-联苯]-4-胺
Wiswesser Line NotationZR DR DF
Beilstein Registry Number2936239
InChIKeyHTRVALPKPVGOSZ-UHFFFAOYSA-N
LabNetwork Molecule IDLN00136962
PubChem Substance ID329788728
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分类

  • {SNA} Amines, Aryl Fluorinated Building Blocks, Building Blocks, C12, C8-C12, Chemical Synthesis, Fluorinated Building Blocks, Nitrogen Compounds, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks

安全信息

Warnings IRRITANT
Hazard Codes T
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R33 Danger of cumulative effects 有累积作用的危险
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,619,1966

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1990 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 175,1131,1955

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2000 mg/kg/W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   BMBUAQ British Medical Bulletin.  (Longman Group UK Ltd., Longman House,
   Burnt Mill, Harlow, Essex CM20 2JE, UK)  V.1-    1943-
   Volume(issue)/page/year: 14,141,1958

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   19,297,1965

RTECSDU9625000
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,619,1966

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 500 ug/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   52,1167,1974

GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger

其他信息

  • 储运特性:库房通风低温干燥
  • 毒性分级:高毒
  • MOL 文件:324-93-6.mol
  • Hazard Note:Toxic
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氟化物烟雾
  • 急性毒性:口服-大鼠LD50: 300 毫克/公斤
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 类别:有毒物品

系列性分类


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