2-Oxoglutaric acid 2-氧代戊二酸

CAS 328-50-7 MFCD00004165

化学结构图

328-50-7
SMILES: O=C(O)CCC(=O)C(=O)O

化学属性

Mol. FormulaC5H6O5
Mol. Weight146.10
Melting Point113-115°C
TSCAYes
Density1.499
Appearance alpha-酮戊二酸(328-50-7)为白色细结晶性粉末。熔点113.5℃。易溶于水、醇、极难溶于醚，久贮变淡灰黄色，易潮解。
Boiling Point345.6°C at 760 mmHg

别名和识别编码

Chemical Name2-Oxoglutaric acid
CAS Number328-50-7
Alfabeta NameKETOGLUTARICACID 2-
MDL NumberMFCD00004165
Synonym 2-Ketoglutaric acid {LY} 2-Ketoglutaric acid {} {LY} 2-Ketoglutaric acid {} {} {LY} 2-Ketoglutaric acid {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ketoglutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2
PubChem Substance ID87571945
EC Number206-330-3
Beilstein Registry Number3,789
Reaxys-RN1705689
Merck Number5303
Chemical Name Translation2-氧代戊二酸
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
LabNetwork Molecule IDLN00174890
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
Canonical SMILESOC(=O)CCC(=O)C(O)=O
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分类

  • {SNA} Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks
  • {SNA} Core Bioreagents, Research Essentials,
  • Activity, Biochemicals and Reagents, Cell Culture, Companion Products and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic, Insect Platform, Serum-free Media
  • {SNA} Activity, Companion Products and Reagents, Enzyme Substrates, Fluorogenic, Insect Platform, 无血清培养基, 生化试剂, 细胞培养, 酶、抑制剂和底物

产品应用

  • 色氨酸分析试剂，谷氨酸脱氢酶的底物(氨基转换酶及脱氢酶)。测定肝功能的配套试剂。

相关文献及参考

  • [2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.
  • Merck: 14,5303
  • Merck: 14,5303 Beilstein:3,789
  • [1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.
  • [1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.
  • [2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Signal word
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
RTECSSA0454200

其他信息

  • TCI Shanghai:2-氧代戊二酸 2-Oxoglutaric Acid,>;99.0%(T)(328-50-7)
  • FEMA:3891
  • 易溶于水、醇、丙酮；极难溶于醚，久贮变淡灰黄色，易潮解。
  • Acros Organics:2-酮戊二酸 2-Ketoglutaric acid, 98%(328-50-7)
  • 用途三:测定氨基转换酶及脱氢酶的底物，测定肝功能的配套试剂，也用作有机合成中间体。
  • 图谱信息:alpha-酮戊二酸(328-50-7)核磁图( 1 HNMR) alpha-酮戊二酸(328-50-7)核磁图( 13 CNMR) alpha-酮戊二酸(328-50-7)红外图谱(IR2) alpha-酮戊二酸(328-50-7)红外图谱(IR1) alpha-酮戊二酸(328-50-7)质谱(MS)
  • alpha-酮戊二酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 69014232 2-酮戊二酸（+4℃） 5g 16.7元 2011/04/16 K0005 2-氧代戊二酸 2-Oxoglutaric Acid 25G 234元 2011/04/16 K0005 2-氧代戊二酸 2-Oxoglutaric Acid 500G 2230元
  • 海关编码:29183000
  • 用途一:主要作为运动营养饮料的成分
  • 用途四:色氨酸分析试剂，谷氨酸脱氢酶的底物(氨基转换酶及脱氢酶)。测定肝功能的配套试剂。
  • 上游原料:丁二酸
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 2-氧代戊二酸 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 方法一:将225g草酰琥珀酸三乙酯与600ml浓盐酸混合，放置过液。蒸馏浓缩至140℃，剩余物冷却结晶，得α-酮基戊二酸110-112g，收率92-93%。
  • Sigma Aldrich:328-50-7(sigmaaldrich)
  • MOL 文件:328-50-7.mol
  • Alfa Aesar:2-酮-1,5-戊二酸,98% 2-Ketoglutaric acid, 98%(328-50-7)
  • MSDS 信息:alpha-Ketoglutaric acid(328-50-7).msds
  • 用途二:用作医药、保健品原料及食品添加剂

系列性分类

  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Substrates - Core Bioreagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Enzyme Substrates - Enzyme Substrates
  6. Activity - Enzyme Substrates
  7. Fluorogenic - Activity
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals and Reagents
  4. Stains and Dyes
  5. Natural Dyes
  1. Medical Research Areas
  2. Metabolism
  3. Tyrosinase  (酪氨酸酶)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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