Naloxone Hcl 盐酸纳洛酮

CAS 357-08-4 MFCD00069322

化学结构图

357-08-4
SMILES: C=CCN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5.Cl

化学属性

Mol. FormulaC19H21NO4.ClH
Mol. Weight363.87
Appearance powder
SolubilitySoluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml), and DMSO (73 mg/ml). Insoluble in ether.
Melting Point200-205 °C

别名和识别编码

Chemical NameNaloxone Hcl
CAS Number357-08-4
Synonym (5?)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one Hydrochloride (5ALPHA)-4,5-EPOXY-3,14-DIHYDRO-17-(2-PROPENYL)MORPHINAN-6-ONE HYDROCHLORIDE (5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one Hydrochloride 17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride 17-Allyl-4,5?-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride 17-Allyl-4,5a-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride 17-allyl-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydrochloride 17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-onehydrochloride 17-烯丙基-4,5a-环氧基-3,14-二羟基吗啡喃-6-酮盐酸盐 17-烯丙基-4,5α-环氧-3,14-二羟基吗啡烷-6-酮 4,5alpha-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride Abello, Naloxone Curamed, Naloxon
MDL NumberMFCD00069322
EC Number206-611-0
Chemical Name Translation盐酸纳洛酮
Wiswesser Line NotationT B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P2U1&GH
LabNetwork Molecule IDLN00355731
PubChem Substance ID5464092
InChIInChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
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分类

  • Chiral Reagents
  • Drug Analogues
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A nonspecific opiate receptor antagonist that displays anitnociceptive effects.

相关文献及参考

  • Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967),
  • McNicholas, L.F., et al.: Drugs, 27, 81 (1984),
  • Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985),

安全信息

Hazard Codes
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Storage condition 储存温度-20°C 储存温度 2-8°C 2-8°C
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany3
RTECSQD2275000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 36,655,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 107 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   YKYUA6 Yakkyo

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 36,655,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 286 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/y

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 560 mg/kg
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NTOTDY Neurobehavioral Toxicology and Teratology.  (Fayetteville, NY) V.3-8,
   1981-86.  For publisher information, see NETEEC. Volume(issue)/page/year:
   3,295,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1800 ug/kg
SEX/DURATION            : lactating female 1 day(s) post-birth
TOXIC EFFECTS :
   Reproductive -

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 3 mg/kg
SEX/DURATION            : lactating female 2 hour(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   39,532,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : female 4-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   11,441,1989

TYPE OF TEST            : TDLo - Lowest published

GHS Symbol
UN Number
Signal word
Precautionary statements
Packing GroupIII

其他信息

  • MOL 文件:357-08-4.mol
  • Naloxone HCl是阿片反向激动剂药物，用来中和过量阿片的效果。
  • color:white to off-white
  • 用途一:麻醉性镇痛药的拮抗剂，可解除麻醉性镇痛药所致呼吸抑制和成瘾性。

系列性分类

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