(p-Chlorophenoxy)Aceticacid2-(Dimethylamino)Ethylesterhydrochloride 盐酸甲氯芬酯

CAS 3685-84-5 MFCD00012533

化学结构图

3685-84-5
SMILES: CN(C)CCOC(=O)COc1ccc(Cl)cc1.Cl

化学属性

Mol. FormulaC12H16ClNO3.ClH
Mol. Weight294.20
Melting Point133-135 ºC
Appearance 白色结晶粉末。

别名和识别编码

Chemical Name(p-Chlorophenoxy)Aceticacid2-(Dimethylamino)Ethylesterhydrochloride
CAS Number3685-84-5
Synonym ######## (4-Chlorophenoxy)acetic acid 2-(dimethylamino)ethyl ester hydrochloride 2-(Dimethylamino)ethyl 4-chlorophenoxyacetate hydrochloride Meclofenoxate hydrochloride (p-chlorophenoxy)aceticacid2-(dimethylamino)ethylesterhydrochloride 2-(DIMETHYLAMINO)ETHYL 4-CHLOROPHENOXYACETATE HYDROCHLORIDE 2-(二甲基氨基)乙基对氯苯氧基乙酸酯盐酸盐 235anphydrochloride Acefen Acephen Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, Atsefen CENTROPHENOXIN CENTROPHENOXINE CENTROPHENOXINE HYDROCHLORIDE Centrophenoxine Centrophenoxine hydrochloride; 4-Chlorophenoxy-acetic acid 2-(dimethylamino)ethyl ester hydrochloride Cerutil Cetrexin Helfergin ME MECLOFENOXAT HYDROCHLORIDE MECLOFENOXATE MECLOFENOXATE HCL
MDL NumberMFCD00012533
EC Number222-975-3
Chemical Name Translation盐酸甲氯芬酯
Merck Number13,5803
Wiswesser Line NotationGR DO1VO2N1&1 &GH
LabNetwork Molecule IDLN00512472
PubChem Substance ID19379
InChIInChI=1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Meclofenoxate is a cerebral stimulant. Also, Meclofenoxate is used as plant growth regulator.

相关文献及参考

  • Liang, A., et al.: Anal. Chim. Acta., 530, 131 (2005),
  • Dong, L., et al.: Microchim. Acta, 159, 49 (2007),
  • Nehru, B., et al.: Brain Res., 1201, 122 (2008),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSAG0440000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Storage condition -20°C
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOS

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #398M

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 153,1914,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 153,1914,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 865 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSKZAN Khimiya v Sel'skom Khozyaistve.  Chemistry in Agriculture.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USS

其他信息

  • 储运特性:库房通风低温干燥
  • 毒性分级:中毒
  • 可燃性危险特性:可燃;加热分解释放极毒氮氧化物, 氯化物和氯化氢烟雾
  • MOL 文件:3685-84-5.mol
  • 灭火剂:干粉、泡沫、砂土
  • 急性毒性:口服-大鼠LD50:865毫克/公斤;口服-小鼠 LD50: 1750 毫克/公斤
  • 用途一:中枢神经兴奋药。
  • 类别:有毒物品

系列性分类


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