Methyl Fluoroacetate (剧毒品,不能销售)氟乙酸甲酯

CAS 453-18-9 MFCD00040096

化学结构图

453-18-9
SMILES: COC(=O)CF

化学属性

Mol. FormulaC3H5FO2
Mol. Weight92.08
Boiling Point104°
Density1.17
Refractive index1.3679
Appearance 无色透明液体。沸点为104.5℃,相对密度为1.1744,闪点-32℃,蒸气压(20℃)为80Pa,折射率为1.3679。
Melting Point-40°C

别名和识别编码

Chemical NameMethyl Fluoroacetate
CAS Number453-18-9
Alfabeta NameMETHYLFLUOROACETATE
MDL NumberMFCD00040096
Synonym FLUOROACETIC ACID METHYL ESTER 甲基氟乙酸酯 TL 551 METHYLESTEROFETODOLAC CHEM-2063 methylesterkyselinyfluoroctove Aceticacid,fluoro-,methylester Methyl fluoroacetate 99% Fluoroacetic acid, methyl ester Methylester kyseliny fluoroctove 氟乙酸甲酯 acetic acid, fluoro-, methyl ester ethanoic acid, fluoro-, methyl ester Fluoressigsäuremethylester Acetic acid, fluoro-, methyl ester Fluoracetic acid methyl ester tl551 fluoroacetic acid methyl ester Fluoroacetic acid methyl ester METHYL FLUOROACETATE Methyl fluoroacetate ethanoic acid,fluoro-,methyl ester fluoro-aceticacimethylester Methylfluoroacetate99% methyl fluoroacetate
EC Number207-218-7
Chemical Name Translation(剧毒品,不能销售)氟乙酸甲酯
Reaxys-RN1740631
PubChem Substance ID9959
Merck Number4167
Wiswesser Line NotationF1VO1
Beilstein Registry Number1740631
InChIInChI=1S/C3H5FO2/c1-6-3(5)2-4/h2H2,1H3
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分类

  • {uni_hamburg} no charge; ester; 1fragment

产品应用

  • 氟乙酸甲酯为生产氟啶酸、环丙氟啶酸、5-氟尿嘧啶、氟苷、喃氟啶、双呋啶、5-氟-4-羟基嘧啶等药物的基本原料。

相关文献及参考

  • Short: IV/20A Title: Vapor Pressure and Antoine Coefficients for Hydrocarbons and Sulfur-, Selenium-, Tellurium-, and Halogen-Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20A Year: 1999 Keyword: organic compounds; vapor pressure ISBN: 3-540-64735-X ISBN: 978-3-540-64735-5 Internet Resource: DOI:10.1007/b71086 RefComment: VIII, 373 pages.
  • Short: IV/20B Title: Vapor Pressure and Antoine Coefficients for Oxygen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20B Year: 2000 Keyword: organic compounds; vapor pressure ISBN: 3-540-64968-9 ISBN: 978-3-540-64968-7 Internet Resource: DOI:10.1007/b71424 RefComment: VII, 320 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Warnings TOXIC 危化品目录(2015) 危险化学品
RTECSAH8400000
Packing GroupI
UN Number 2929 3272
Signal word
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H300 Fatal if swallowed 吞食致命
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310+P330
  • P301+P316
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes T
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R10 Flammable 易燃
Hazard Class6.1/3
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 600 ug/kg
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 87,90,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB158-508

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SP

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than

Restrict 剧毒化学品

其他信息

  • TCI Shanghai:氟乙酸甲酯 Methyl Fluoroacetate,>;99.0%(GC)(453-18-9)
  • 用途一:用作医药、农药、染料中间体
  • 方法一:由氯乙酸甲酯与氟化钾反应而得。
  • 用途二:氟乙酸甲酯为生产氟啶酸、环丙氟啶酸、5-氟尿嘧啶、氟苷、喃氟啶、双呋啶5-氟-4-羟基嘧啶等药物的基本原料,也是农药、香料中间体。
  • MOL 文件:453-18-9.mol
  • 上游原料:氟化钾 --> 氯乙酸甲酯
  • Hazard Note:Toxic
  • 氟乙酸甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0183 氟乙酸甲酯 Methyl Fluoroacetate 25G 1420元 2014/06/02 F0183 氟乙酸甲酯 Methyl Fluoroacetate 250G 7090元
  • 图谱信息:氟乙酸甲酯(453-18-9)质谱(MS) 氟乙酸甲酯(453-18-9)核磁图( 1 HNMR) 氟乙酸甲酯(453-18-9)红外图谱(IR1) 氟乙酸甲酯(453-18-9)核磁图( 13 CNMR)
  • 用途三:氟乙酸甲酯为生产氟啶酸、环丙氟啶酸、5-氟尿嘧啶、氟苷、喃氟啶、双呋啶、5-氟-4-羟基嘧啶等药物的基本原料。

系列性分类


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