DL-Fenfluramine

CAS 458-24-2 MFCD00864474

化学结构图

458-24-2
SMILES: CCNC(C)Cc1cccc(C(F)(F)F)c1

化学属性

Mol. FormulaC12H16F3N
Mol. Weight231.29

别名和识别编码

Chemical NameDL-Fenfluramine
Wiswesser Line NotationFXFFR C1YM2
Synonym 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)- Fenfluramine Fenfluramine Hydrochloride Fenfluramine Hydrochloride, (+-)-Isomer Fenfluramine Hydrochloride, R Isomer Fenfluramine Hydrochloride, R-Isomer Fenfluramine, (+-)-Isomer Fenfluramine, R Isomer Fenfluramine, R-Isomer Fintepla Hydrochloride, Fenfluramine Isomeride N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine Pondimin
Beilstein Registry Number4783711
CAS Number458-24-2
PubChem Substance ID3337
InChIInChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
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安全信息

RTECSSH6820000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle contraction or spasticity
   Cardiac - other changes
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1306,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,177,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - hair
REFERENCE :
   17XKAB "International Symposium on Amphetamines and Related Compounds,
   Proceedings, Mario Negri Institute for Pharmacological Research, Milan,
   1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970
   Volume(issue)/page/year: -,75,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - hair
REFERENCE :
   17XKAB "International Symposium on Amphetamines and Related Compounds,
   Proce

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 280 mg/kg
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 17,39A,1978

Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P316
  • P301+P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
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