Aristolochic Acid B Aristolochic

CAS 475-80-9 MFCD01708574

化学结构图

475-80-9
SMILES: O=C(O)c1cc2c(c3c1c([N+](=O)[O-])cc1ccccc13)OCO2

化学属性

Mol. FormulaC16H9NO6
Mol. Weight311.26

别名和识别编码

Chemical NameAristolochic Acid B
CAS Number475-80-9
Synonym Aristolochic acid II 6-Nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid 6-Nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid Aristolochic acid B
MDL NumberMFCD01708574
EC Number207-499-6
Chemical Name TranslationAristolochic
Beilstein Registry Number0329754
LabNetwork Molecule IDLN01279657
PubChem Substance ID108168
InChIInChI=1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Aristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids.

相关文献及参考

  • Coutts, et al.: J. Pharm. Pharmacol., 11, 607 (1959),
  • Kupchan, D., et al.: J. Med. Pharm. Chem., 5, 657 (1962),
  • Mix, D.B., et al.: J. Nat. Prod., 45, 657 (1982),

安全信息

RTECSSF8281600 
TYPE OF TEST            : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 128 ug/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10,275,1987

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 40 mg/kg/2W (Intermittent)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 15,1187,1994

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 20 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10,275,1987

GHS Symbol
UN Number
Hazard Codes
Signal word
WGK Germany3
Precautionary statements
Packing GroupIII

系列性分类

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