TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - other changes
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   33,51,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 71428 ug/kg/10D-I
TOXIC EFFECTS :
   Behavioral - rigidity (including catalepsy)
   Skin and Appendages - sweating
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   ICMED9 Intensive Care Medicine.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.3-    1977-
   Volume(issue)/page/year: 23,480,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - changes in motor activity (specific assay)
   Behavioral - coma
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verlag,
   Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.50-    1978-
   Volume(issue)/page/year: 55,527,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - changes in motor activity (specific assay)
   Behavioral - coma
REFERENCE :
   HEPHD2 Handbook of Experimental Pharmacology.  (Springer-Verl

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 188 mg/kg/5D (Intermittent)
REFERENCE :
   IMSCE2 IRCS Medical Science.  (Lancaster, UK)  V.12-14, 1984-86.  For
   publisher information, see MSCREJ.  Volume(issue)/page/year: 14,1129,1986

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 gm/L
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 47,182a,1970

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 75 mg/kg/24H
REFERENCE :
   IMSCE2 IRCS Medical Science.  (Lancaster, UK)  V.12-14, 1984-86.  For
   publisher information, see MSCREJ.  Volume(issue)/page/year: 14,1129,1986

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 gm/L
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 47,182a,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 87500 ug/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 4,855,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 80 ug/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year:
   -,207,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 18-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   ADBBBW Advances in Behavioral Biology.  (Plenum Pub. Corp., 233 Spring St.,
   New York, NY 10013) V.1-    1971-  Volume(issue)/page/ye

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : female 8-20 day(s) after conception
TOXIC EFF

• H302 Harmful if swallowed 吞食有害
• H400 Verytoxictoaquaticlife 对水生生物毒性非常大。

• P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
• P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
• P273 Avoid release to the environment. 避免释放到环境中。
• P301+P312
• P330 Rinse mouth. 漱口
• P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
• P501 Dispose of contents/container to..… 处理内容物/容器.....