14-Hydroxy Codeinone 14-Hydroxy

CAS 508-54-3 MFCD N/A

化学结构图

508-54-3
SMILES: COc1ccc2c3c1OC1C(=O)C=CC4(O)C(C2)N(C)CCC314

化学属性

Mol. Weight313.38
Mol. FormulaC18H19NO4

别名和识别编码

CAS Number508-54-3
Chemical Name14-Hydroxy Codeinone
Synonym (5?)-7,8-Didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one 14-Hydroxycodeinone 14-beta-Hydroxycodeinone 14-hydroxycodeinone 7,8-Didehydro-4,5.alpha.-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one Hydroxycodeinone Morphinan-6-one, 7,8-didehydro-4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, hydroxycodeinone hydroxycodeinone, (5beta,9alpha,13alpha,14alpha)-isomer
Wiswesser Line NotationT B6566 B6/CO 4ABBC R BX FV HO PN DU GHT&&TTJ CQ JO1P1
Beilstein Registry Number4552573
Chemical Name Translation14-Hydroxy
PubChem Substance ID9926820
InChIInChI=1S/C18H19NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-6,13,16,21H,7-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • An intermediate in the preparation of Oxycodone and other alkaloid based opiate antagonists.

相关文献及参考

  • Brogle, K., et al.: J. Pharm. Biomed. Anal., 19, 669 (1999),
  • Szentesi, A., et al.: Anal. Bioanal. Chem., 374, 427 (2002),

安全信息

RTECSGG8225000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   28ZNAE "Public Health Reports, Supplement."  (Washington, DC)
   Volume(issue)/page/year: 138,27,1938

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11800 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16(Suppl),68T,1964

系列性分类

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