苯乙肼 苯乙基-肼

CAS 51-71-8 MFCD00047825

化学结构图

51-71-8
SMILES: NNCCc1ccccc1

化学属性

Mol. FormulaC8H12N2
Mol. Weight136.22
Boiling Point74°

别名和识别编码

Chemical NamePhenelzine
CAS Number51-71-8
Alfabeta NamePHENETHYLHYDRAZINE -
MDL NumberMFCD00047825
Synonym Fenelzyna 2-Phenylethylhydrazine Stinerval nadil 1-(2-Phenylethyl)hydrazine Hydrazine, (2-phenylethyl)- phenethyl-hydrazin ASINEX-REAG BAS 07650440 beta-Phenylethylhydrazine 1-Hydrazino-2-phenylethane W1544 Phenethylhydrazine Phenelzine Nardil BETA-PHENYLETHYLHYDRAZINE Nadil PHENELZINE PHENETHYL HYDRAZINE W 1544-A 1-hydrazino-2-phenylethane 苯乙肼 2-Phenethylhydrazine (2-PHENYL-ETHYL)-HYDRAZINE Phenalzine 2-PHENELZINE Hydrazine, phenethyl- (2-phenylethyl)-hydrazin Phenylethylhydrazine Fenelzyne
EC Number200-117-9
Chemical Name Translation苯乙基-肼
Wiswesser Line NotationZM2R
Beilstein Registry Number0742354
LabNetwork Molecule IDLN00126164
PubChem Substance ID3675
InChIInChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

安全信息

Warnings IRRITANT
Hazard Codes Xi
RTECSMV8400000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 32,526,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 37,651,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 7500 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 130,507,1976

TYPE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Liver - fatty liver degeneration
REFERENCE :
   JATOD3 Journal of Analytical Toxicology.  (Preston Pub. Inc., POB 48312,
   Niles, IL 60648) V.1-    1977-  Volume(issue)/page/year: 19,265,1995

TYPE OF TEST

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 38800 ug/kg/24H
REFERENCE :
   IMSCE2 IRCS Medical Science.  (Lancaster, UK)  V.12-14, 1984-86.  For
   publisher information, see MSCREJ.  Volume(issue)/page/year: 14,1052,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 450 mg/kg
SEX/DURATION            : male 4 day(s) pre-mating
                          female 4 day(s) pre-mating  - 10 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   PENDAV Polish Endocrinology.  English translation of Endokrynologia Polska.
   (Springfield, VA) V.13-23, 1962-72.  Discontinued. Volume

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 175 mg/kg
SEX/DURATION            : female 16-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   PENDAV Polish Endocrinology.  English translation of Endokrynologia Polska.
   (Springfield, VA) V.13-23, 1962-72.  Discontinued. Volume(issue)/page/year:
   16,21,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 250 mg/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   PENDAV Polish Endocrinology.  English translation of Endokrynologia Polska.
   (Springfield, VA) V.13-23, 1962-72.  Discontinued. Volume(issue)/page/year:
   16,21,1965

其他信息

  • MOL 文件:51-71-8.mol
  • 抗抑郁症药:苯乙肼是一种抗抑郁躁狂药，属单胺氧化酶抑制剂，抗抑郁作用与尼亚酰胺相似，可减少脑内儿茶酚胺(去甲肾上腺素、多巴胺、5-羟色胺)的降解，使儿茶酚胺含量增多，而起抗抑郁作用。对内源性抑郁症效果较好，对外源性及反应性抑郁症效果不佳。 硫酸苯乙肼在重型抑郁症，心境恶劣性障碍和非典型抑郁症的治疗中是有效的，它对治疗惊恐性障碍和恐怖性障碍都有作用。某些使用三环类药物难于治疗的患者，尤其是非典型抑郁症或严重焦虑症患者，采用苯乙肼则可能有效。 苯乙肼在某些贪食症患者可改善其饮食习惯，然而，其对此病的确切作用还有待于临床对照试验的结果。 由于苯乙肼的毒性大，目前在临床上已经很少使用。 以上信息由Chemicalbook的瑶瑶编辑整理。
  • Sigma Aldrich:51-71-8(sigmaaldrich)
  • 不良反应与注意事项:1. 常见的不良反应为直立性低血压及自主神经功能紊乱，如口干、水肿、便秘、失眠、恶心，也可有震颤、共济失调、反射亢进等。超量时导致昏厥、多汗、脉快、呼吸表浅等，可肌内注射氯丙嗪对抗。 2. 苯乙肼对肝脏有毒性反应，可造成肝损害，长期用药应定期检查肝功能。肝功能不全者禁用。 3. 肾功能不全、高血压及癫痫病人慎用。 4. 不能突然停药，在用三环类抗抑郁药（如：盐酸丙咪嗪、盐酸阿米替林、盐酸去甲替林、盐酸麦普替林、盐酸普罗替林、三甲丙咪嗪等）同时或先后均不可使用本品，以免产生毒性。 5. 苯乙肼与抗胆碱药、抗组胺药、降糖药、降压药、巴比妥类及麻醉药均不得合用。

系列性分类

相关产品推荐