Urethane 氨基甲酸乙酯

CAS 51-79-6 MFCD00007966

化学结构图

51-79-6
SMILES: CCOC(N)=O

化学属性

Mol. FormulaC3H7NO2
Mol. Weight89.09
Density1.1
Vapor Density3.07 (vs air)
Boiling Point184°C at 760 mmHg
Vapor Pressure10 mmHg ( 77.8 °C)
Melting Point48-50°C
Flash Point92.22°C
TSCAYes
Solubility略溶于水
Stability对湿度敏感
Appearance 无色结晶或白色粉末,易燃,无臭,具有清凉味,与硝石相似。熔点48-50℃,沸点182-184℃,103℃(7.2kPa)时升华,相对密度0.9862,闪点92℃。易溶于水、乙醇、乙醚和甘油,微溶于三氯甲烷和橄榄油。水溶液呈中性。
pH:A

别名和识别编码

Chemical NameUrethane
CAS Number51-79-6
Synonym Urethane {LY} Urethane {} {LY} Urethane {} {} {LY} Urethane {} {} {} {LY} Urethane {} {} {} {} {LY} Urethane {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {}
EC Number200-123-1
Beilstein Registry Number635810
MDL NumberMFCD00007966
PubChem Substance ID87565237
Merck Number9874
Reaxys-RN635810
Chemical Name Translation氨基甲酸乙酯
Wiswesser Line NotationZVO2
LabNetwork Molecule IDLN00194423
InChIInChI=1S/C3H7NO2/c1-2-6-3(4)5/h2H2,1H3,(H2,4,5)
Canonical SMILESNC(OCC)=O
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分类

  • Mutagenesis Research Chemicals
  • {SNA} All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Ester, Esters, Flavors and Fragrances, Food & Beverage Standards, S-Z, Standards for Personal Care and Cosmetic Products, Substance Classification, neats, prohibited substances (EU-REGULATION No 1223/2009)
  • {SNA} All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Chromatography, Ester, Flavors and Fragrances, Food & Beverage Standards, S-Z, Substance Classification
  • {SNA} Amides, Buildi
  • {uni_hamburg} no charge; carbamate; 1fragment

产品应用

  • 生化研究,有机合成,溶剂。

相关文献及参考

  • Merck: 14,9874 Beilstein:3,22
  • Mirvish, S.S., et al.: Adv. Cancer Res., 11, 1 (1968),
  • Short: II/27B
  • Franklin, K.J., et al.: J. Pharmacol. Exp. Ther., 42, 1 (1931),
  • Merck: 14,9874
  • Battaglia, R., et al.: Food Addit. Contam., 7, 477 (1990),
  • Short: II/2

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R45 May cause cancer 可能致癌
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P302+P352+P312+P362+P364
  • P304+P340+P312
  • P305+P351+P338
  • P308+P313
  • P313 Get medical advice/attention. 获取医疗咨询/就医
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312
  • H350 May cause cancer 可能致癌
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSFA8400000
Hazard Codes 9 T
Packing GroupIII
UN Number 3077
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/m3/10D-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 81,742,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
                          female 11 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 gm/kg/56W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,911,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1000 mg/kg/W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22,

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
   Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed.
   Rep. Ger., 1931  Volume(issue)/page/year: -,-,1931

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1809 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   57,37,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 84,227

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - peritonitis
REFERENCE :
   NCISA* Progress Report for Contract No. PH-43-63-1132, Submitted to the
   National Cancer Institute by Scientific Associates, Inc.  (6200 S. Lindberg
   Blvd., St. Louis, MO 63123)  Volume(issue)/page/year: PH-43-62-483

TYPE OF TEST            : LDLo - Lowest published lethal d

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 56200 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,195,1970

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 55000 ppm/6H
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(iss

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1000 ppm
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 6,45,1958

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 2 mg/disc
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/p

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   24,68,1994

TYPE OF TEST            : TDLo - Lowest publ

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 81,174,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : male 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   HIKYAJ Hinyokika Kiyo.  Journal of Urology.   (Kyoto Daigaku Igakubu,
   Hinyokikagaku Kyoshitsu, 54 Kawara-machi, Shogain, Sakyo-ku, Kyoto 606,
   Japan)  V.1-    1955-  Volume(issue)/page/year: 12,1339,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 81,174,1966

TYPE OF TEST            : TDLo - Lowest

TYPE OF TEST            : TDLo - Lo

其他信息

  • 用途二:该品用作医药、农药、香料的中间体,用于生产安眠药、镇静剂。用作马钱子碱、间苯二酚的解毒剂、杀菌剂、注射剂的助溶剂和印染工业着色剂,也可用于生物化学研究。此外,尿烷本身可作成药使用,具有抗癌性能,用于治疗多发性骨髓瘤和慢性白血病等。
  • MOL 文件:51-79-6.mol
  • TCI Shanghai:氨基甲酸乙酯 Ethyl Carbamate,>;98.0%(GC)(N)(51-79-6)
  • 氨基甲酸乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30191228 乌来糖 500g 52.7元 2011/04/16 C0028 氨基甲酸乙酯 Ethyl Carbamate 25G 219元 2011/04/16 C0028 氨基甲酸乙酯 Ethyl Carbamate 500G 1320元
  • Acros Organics:Urethane, 99%(51-79-6)
  • 常规方法:采用纸板桶包装,内衬塑料袋,每桶25kg。要密封避光存放。贮于阴凉、通风、干燥处,运输中防火、防晒、防潮。按有毒化学品规定贮运。
  • 下游产品:双甲眯 --> 2,4-二氯-5-氰基嘧啶 --> 乙吗噻嗪 --> 1-环己基尿嘧啶 --> 1-环己基-1,2,3,4-四氢-2,4-二氧嘧啶-5-腈 --> 奈法唑酮 --> 羟基脲 --> N,N-二氯氨基甲酸乙酯 --> 双氧威
  • Alfa Aesar:Ethyl carbamate, 98%(51-79-6)
  • 无臭,味凉而咸。103℃(7.20kPa)时升华。易溶于水、醇、醚、甘没、氯仿和橄榄油,1g溶于0.5ml水、0.8ml乙醇、0.9ml氯仿、1.5ml乙醚、2.5ml甘油和32ml橄榄油,水溶液呈中性。有潜在致癌作用。
  • 用途一:用于有机合成及生化研究
  • Sigma Aldrich:51-79-6(sigmaaldrich)
  • MSDS 信息:Carbamic acid ethyl ester(51-79-6).msds
  • 方法一:硝酸与尿素反应生成硝酸尿素,然后加乙醇、亚硝酸钠,在硫酸存在下,进行酯化反应,生成尿烷和硝酸钠,反应产物经过滤除去硝酸钠,再经蒸馏、结晶、干燥,制得成品。原料消耗定额:硝酸(96%)1230kg/t、尿素116kg/t、乙醇330kg/t、亚硝酸钠1370kg/t。
  • 蒸气密度:3.07 (vs air)
  • 蒸气压:10 mm Hg ( 77.8 °C)
  • 图谱信息:氨基甲酸乙酯(51-79-6)红外图谱(IR2) 氨基甲酸乙酯(51-79-6)质谱(MS) 氨基甲酸乙酯(51-79-6)核磁图( 1 HNMR) 氨基甲酸乙酯(51-79-6)核磁图( 13 CNMR) 氨基甲酸乙酯(51-79-6)红外图谱(IR3) 氨基甲酸乙酯(51-79-6)红外图谱(IR1) 氨基甲酸乙酯(51-79-6)Raman光谱
  • 防护措施:本品有毒。对家兔静脉注射LD50为2000mg/kg体重。白鼠口服LD50为2700mg/kg体重。生产设备应注意密闭性良好,防止跑、冒、滴、漏,贮存容器应标以有毒标记,防止误食。操作人员应戴橡皮手套。皮肤沾染后,用清水和肥皂洗净;如发生误食应及时就医。

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