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分类

• Pharmaceuticals
• Aliphatics
• Intermediates & Fine Chemicals,
• {SNA} Agonists, Bioactive Small Molecule Alphabetical Index, C-CH, Cholinergics, Neuroscience, Neurotransmission, Neurotransmitters, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
• {SNA} Ammonium Salts, Bioactive Small Molecules, C-CH, Cell Biology, Chemical Synthesis, Phase Transfer Catalysts, Synthetic Reagents

产品应用

• Carbamylcholine Chloride is a cholinergic receptor agonist. Studies show that Carbamylcholine Chloride is resistant to the action of cholinesterases. Carbamylcholine Chloride also displays antiapoptot

相关文献及参考

• Yan, G.M. et al.: Mol. Pharmacol., 47, 248 (1995); Pugh, P.C. et al.: Mol. Cell. Neurosci., 15, 113 (2000);

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 58,337,1936

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2857 ng/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 113,79,1933

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 20(4),32,1957

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1428 ng/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Vascular - regional or general arteriolar or venous dilation
   Gastrointestinal - nausea or vomiting
REFERENCE :
   CRSBAW Comptes Rendus des Seances

其他信息

• 急性毒性:口服-大鼠 LD50: 40 毫克/公斤; 口服-小鼠 LD50: 15 毫克/公斤
• 毒性分级:剧毒
• 可燃性危险特性:热分解排出有毒氮氧化物, 氯化物烟雾
• 上游原料:尿素 --> 2-氯乙醇 --> 三甲胺 --> 氯化胆碱
• 类别:有毒物质
• MOL 文件:51-83-2.mol
• 卡巴胆碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 108240050 卡巴胆碱 Carbamylcholine chloride 99% 5 GR 699元
• 灭火剂:水, 二氧化碳, 泡沫, 干粉
• 图谱信息:卡巴胆碱(51-83-2)质谱(MS) 卡巴胆碱(51-83-2)红外图谱(IR1) 卡巴胆碱(51-83-2)红外图谱(IR2)
• 储运特性:库房低温通风干燥; 与食品原料分开存放
• 方法一:以β-氯乙醇为原料，经光气酰化，制得氯甲酸-β-氯乙酯：然后与氨反应生成氨基甲酸-β-氯乙酯，最后与三甲胺成季铵盐反应而得卡巴胆碱：卡巴胆碱的另一种制法是采用氯化胆碱和尿素为原料：当采用配料比氯化胆碱：尿素：亚硝酸钠：硫酸=1：1：1.15：1.35，在60℃反应约40h，能以71%的收率获得得卡巴胆碱。
• color:white
• 用途一:该品为拟胆碱药，也用作副交感神经兴奋药。作兽药时用于大动物，治疗马的急性腹痛等。小鼠口服LD50为15mg/kg，静脉注射为0.3mg/kg。
• Alfa Aesar:卡巴可,99% Carbachol, 99%(51-83-2)
• 敏感性:Hygroscopic
• Sigma Aldrich:51-83-2(sigmaaldrich)
• Acros Organics:Carbamylcholinechloride,99%(51-83-2)