Uracil, 5-(bis-(2-chloroethyl)amino)-6-methyl-

CAS 520-09-2 MFCD00233543

化学结构图

520-09-2
SMILES: Cc1[nH]c(=O)[nH]c(=O)c1N(CCCl)CCCl

化学属性

Mol. FormulaC9H13Cl2N3O2
Mol. Weight266.15

别名和识别编码

Chemical NameUracil, 5-(bis-(2-chloroethyl)amino)-6-methyl-
Wiswesser Line NotationT6MVMVJ EN2G2G F1
Synonym Dopan 5-(Bis(2-chloroethyl)amino)-6-methyluracil ENT 50698 5-(Bis-(2-cloroetil)-amino)-6-metiluracile 4-Methyl-5-(bis(beta-chloroethyl)amino)uracil 2,6-Dihydroxy-4-methyl-5-bis(2-chloroethyl)aminopyrimidine Dopane Elderfield pyrimidine mustard Chloroethylaminouracil 6-Methyl-5-(bis(2-chloroethyl)amino)uracil
CAS Number520-09-2
PubChem Substance ID68216
InChIInChI=1S/C9H13Cl2N3O2/c1-6-7(8(15)13-9(16)12-6)14(4-2-10)5-3-11/h2-5H2,1H3,(H2,12,13,15,16)
LabNetwork Molecule IDLN00262528
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安全信息

RTECSYQ9000000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   101,630,1962

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 34,83,1971

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 22,105,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Primate - monkey Kidney
DOSE/DURATION           : 100 mg/L
REFERENCE :
   TSITAQ Tsitologiya.  Cytology.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1959-  Volume(issue)/page/year: 15,1505,1973

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 22,105,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   TSITAQ Tsitologiya.  Cytology.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1959-  Volume(issue)/page/year: 15,1505,1973

系列性分类

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