2,2,4,4,6,6-hexaaziridin-1-yl-1,3,5-triaza-2$l^{5},4$l^{5},6$l^{5}-triphosphacyclohexa-1,3,5-triene

CAS 52-46-0 MFCD N/A

化学结构图

52-46-0
SMILES: C1CN1P1(N2CC2)=NP(N2CC2)(N2CC2)=NP(N2CC2)(N2CC2)=N1

化学属性

Mol. FormulaC12H24N9P3
Mol. Weight387.36

别名和识别编码

Chemical Name1,3,5,2,4,6-Triazatriphosphorine,2,2,4,4,6,6-hexakis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-
Chemicalbook IDCB01261048
Wiswesser Line NotationT6NPNPNPJ B- AT3NTJ& B- AT3NTJ& D- AT3NTJ& D- AT3NTJ&F- AT3NTJ& F- AT3NTJ
Synonym APN 2,2,4,4,6,6-Hexakis(1-aziridinyl)cyclotriphosphaza-1,3,5-triene 1-Aziridinylphosphonitrile trimer Apholate PN6 Hexakis-(1-aziridinyl)phosphonitrile Hexakis(aziridinyl)phosphotriazine ENT 26,316 Olin MO. 2174 Hexa(1-aziridinyl)triphosphotriazine SQ 8388 Aziridine, 1,3,5,2,4,6-triazatriphosphorine derivative Pholate 2,2,4,4,6,6-Hexakis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-1,3,5,2,4,6-triazatriphosphorine NSC-26812 Afolat
CAS Number52-46-0
Beilstein Registry Number1334691
PubChem Substance ID5845
InChIInChI=1S/C12H24N9P3/c1-2-16(1)22(17-3-4-17)13-23(18-5-6-18,19-7-8-19)15-24(14-22,20-9-10-20)21-11-12-21/h1-12H2
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安全信息

RTECSXX9450000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 29,1341,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in spleen
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 8,73,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 98 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,515,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 246 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - food intake (animal)
   Behavioral - ataxia
REFERE

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 ppm
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 2700 ng
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 7,63,1969

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 ppm
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/ye

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 pph
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 500 ppm
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 2500 ng
R

TYPE OF TEST            : Cytogenetic

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 24,924,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 200

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   85GUAJ "Antifertility Compounds in the Male and Female," Jackson, H.,
   Springfield, IL, Charles C. Thomas, 1966  Volume(issue)/page/year: -,37,1966

系列性分类

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