4'-Hydroxysalicylanilide 柳胺酚

CAS 526-18-1 MFCD00020026

化学结构图

526-18-1
SMILES: O=C(Nc1ccc(O)cc1)c1ccccc1O

化学属性

Mol. FormulaC13H11NO3
Mol. Weight229.238
Appearance 白色结晶、无嗅。熔点179℃。易溶于甲醇、乙醇、丙酮、乙醚，微溶于热水、苯、甲苯，不溶于水和乙酸。

别名和识别编码

Chemical Name4'-Hydroxysalicylanilide
CAS Number526-18-1
EC Number208-385-9
Synonym 2-Hydroxy-N-(4-hydroxyphenyl)-benzamide {Chemicalbook} 4’-hydroxy-salicylanilid 4’-hydroxysalicylanilide Auxobil Benzamide, 2-hydroxy-N-(4-hydroxyphenyl)- Bilene Bilocol Dribazil Driol Driol-labaz Enidran Hydroxyphenyl salicylamide L 1718 LOIRD N-(4-HYDROXYPHENYL)SALICYLAMIDE N-(4-Hydroxyphenyl)salicylamide N-(4-羟基苯基)水杨酰胺 (柳胺酚) N-(p-Hydroxyphenyl)salicylamide N-(对-羟基苯基)水杨酰胺 {} {Chemicalbook} 4-羟基水杨酰苯胺 {} {} {Chemicalbook} 4-Hydroxysalicylanilide {} {} {} { {} {} {} {hazard_com} 4'-Hydroxysalicylanilide {} {} {} {} {} {} {} {} {Chemicalbook} 2-羟基-N-(4-羟基苯基)苯甲酰胺 {} {} {} {} {} {Chemicalbook} 2-hydroxy-n-(4-hydroxyphenyl)-benzamide {} {} {} {} {} {} {Chemicalbook} 2-hydroxy-n-(4
MDL NumberMFCD00020026
Chemical Name Translation柳胺酚
Wiswesser Line NotationQR BVMR DQ
Beilstein Registry Number2941480
LabNetwork Molecule IDLN00224242
PubChem Substance ID4602
InChIInChI=1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)
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安全信息

RTECSVN8830000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03234

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6702 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,159,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gas

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,159,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie e

其他信息

  • Sigma Aldrich:526-18-1(sigmaaldrich)
  • 上游原料:4-氨基苯酚 --> 水杨酸苯酯
  • 用途二:用于治疗急、慢性胆囊炎、胆结石排石症，同时又有退黄胆作用
  • 用途三:本品为利胆药。
  • MOL 文件:526-18-1.mol
  • 用途一:用于胆囊炎、胆道炎、胆石症及胆道手术后综合征
  • 方法一:由水杨酸苯酯与对氨基苯酚反应而得。

系列性分类

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