DL-Pipecolic Acid 六氢吡啶-alpha-羧酸

CAS 535-75-1 MFCD00064347

化学结构图

535-75-1
SMILES: O=C(O)C1CCCCN1

化学属性

Mol. FormulaC6H11NO2
Mol. Weight129.16
Melting Point282 °C
TSCAT
Density1.125
Appearance 白色结晶性粉未，溶于乙醇及水中。
Stability对光敏感
Solubilitysoluble
Boiling Point239.22 °C at 760 mmHg

别名和识别编码

Chemical NameDL-Pipecolic Acid
CAS Number535-75-1
Alfabeta NamePIPERIDINECARBOXYLICACID 2--
MDL NumberMFCD00064347
EC Number208-616-3
Beilstein Registry Number81095
Synonym Pipecolic acid {LY} Pipecolic acid {} {LY} Pipecolic acid {} {} {LY} Pipecolic acid {} {} {} {LY} Pipecolic acid {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pipecolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Merck Number7458
PubChem Substance ID849
Chemical Name Translation六氢吡啶-alpha-羧酸
Reaxys-RN81095
LabNetwork Molecule IDLN00008325
InChIInChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)
Canonical SMILESO=C(O)C1CCCCN1
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分类

  • {SNA} Chemical Biology, Chemical Synthesis, Peptide Chemistry, Proline Derivatives, Unnatural Amino Acid Derivatives
  • {SNA} Chemical Biology, Chemical Synthesis, Peptide Chemistry, Proline Derivatives, Unnatural Amino Acids & Derivatives

相关文献及参考

  • [2]. Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5.
  • [1]. He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7.
  • [1]. He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7.
  • [2]. Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5.

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSTK6021000
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 610 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CEXPB9 Clinical and Experimental Pharmacology and Physiology.  (Blackwell
   Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic.
   3053, Australia)  V.1-  1974-  Volume(issue)/page/year: 21,997,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 23,1343,1968

其他信息

  • MOL 文件:4043-87-2.mol
  • MSDS 信息:DL-Pipecolic acid(4043-87-2).msds
  • 检测方法:T,NMR
  • 用途一:用作医药中间体
  • TCI Shanghai:DL-哌啶-2-甲酸 DL-Pipecolic Acid,>;98.0%(T)(535-75-1)
  • 下游产品:(1-甲基-2-哌啶)甲胺 --> 2-(叔丁氧羰基氨基甲基)-哌啶
  • MOL 文件:535-75-1.mol
  • 六氢吡啶-alpha-羧酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0442 DL-哌啶甲酸 DL-Pipecolic Acid 25G 690元 2014/06/02 P0442 DL-哌啶甲酸 DL-Pipecolic Acid 250G 3920元 2010/06/21 131281000 六氢吡啶-alpha-羧酸 DL-Pipecolinic acid 99% 100 GR 2356元
  • Alfa Aesar:DL-2-哌啶酸,99% DL-Pipecolinic acid, 99%(535-75-1)
  • Hazard Note:Irritant
  • Sigma Aldrich:535-75-1(sigmaaldrich)
  • Sigma Aldrich:4043-87-2(sigmaaldrich)
  • TSCA:T
  • 2-哌啶甲酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010319 2-哌啶甲酸 25g 400元
  • Acros Organics:DL-2-哌啶甲酸 DL-Pipecolinic acid, 99%(535-75-1)
  • 下游产品:(1-甲基-2-哌啶)甲胺

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Unnatural Amino Acid Derivatives 人工合成氨基酸
  5. Proline Derivatives 脯氨酸衍生物
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Unnatural Amino Acid Derivatives 人工合成氨基酸
  5. Proline Derivatives 脯氨酸衍生物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Heterocyclic Acids 杂环酸
  5. Piperidine Acids
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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