• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones, 细胞生物学
• {SNA} Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
• {Chemicalbook} 生物化学品: 生化试剂: 激素
• Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
• {SA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules
• {SNA} Bioactive Small Molecule Alphabetical Index, Corticosteroid, Cytokines, Growth Factors and Hormones, D-DIF,

产品应用

• Adrenocortical/mineralocorticoid Steroid.

相关文献及参考

• Quigley, J., et al.: Clin. Exper. Pharmacol. Physiol., 36, 724 (2009),
• Merck 14 ,2901
• Beil. 8 ,IV,2195
• FT-NMR 1 (3), 602:C / Structure Index 1 , 460:D:5

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg/13W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 83,14,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16 mg/kg
SEX/DURATION            : male 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   ANENAG Annales d'Endocrinologie.  (Masson Editeur, 120 Blvd. Saint-Germain,
   F-25280 Paris Cedex 06, France)  V.1-    1939-  Volume(issue)/page/year:
   24(Suppl 3),1,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 316 mg/kg
SEX/DURATION            : female 56 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 120,238,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 224 mg/kg
SEX/DURATION            : female 56 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 120,238,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE

其他信息

• 下游产品:21-羟基-5α-孕甾(烷)-3,20-二酮
• MSDS 信息:21-Hydroxy-4-pregnene-3,20-dione 21-acetate(56-47-3).msds
• Sigma Aldrich:56-47-3(sigmaaldrich)
• TCI Shanghai:乙酸去氧皮质酮 Deoxycorticosterone Acetate,>;98.0%(LC)(56-47-3)
• 用途一:生化研究，肾上腺皮质激素类药物，具有抗炎、抗过敏等作用。
• Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。
• 上游原料:四氢呋喃 --> 氧化钙 --> 乙酸钾 --> 孕酮 --> 无水丙酮
• 醋酸去氧皮质酮
• 参考质量标准:含量达96.0%-104.0%，mp157-161℃；比旋光度[α] 20 D +179°-+184°；吸光度(A)0.43-0.45(0.001%，240nm)；检测氟化物、干燥失重及灰分等杂质含量。
• 方法一:黄体酮在四氢呋喃和甲醇混合溶液中与氧化钙和碘发生碘代反应，再与醋酸钾在无水丙酮中反应成酯，最后精制而得。
• 用途二:羟孕酮琥酯钠的中间体。
• MOL 文件:56-47-3.mol