2-(Diethylamino)Ethyl 2-Hydroxy-2,2-Diphenylacetate Hydrochloride 2-(二乙氨基)乙基-2-羟基-2,2-二苯基乙酸酯盐酸盐

CAS 57-37-4 MFCD00012624

化学结构图

57-37-4
SMILES: CCN(CC)CCOC(=O)C(O)(c1ccccc1)C1CCCCC1.Cl

化学属性

Mol. FormulaC20H25NO3·HCl
Mol. Weight363.88
Melting Point175.0 to 179.0 deg-C
Appearance 白色或几乎白色结晶性粉末。熔点177-181℃。25℃时100ml水中可溶解该品14.9g,几乎不溶于乙醚。无臭,味微苦。其碱基([302-40-9])熔点51℃。

别名和识别编码

Chemical Name2-(Diethylamino)Ethyl 2-Hydroxy-2,2-Diphenylacetate Hydrochloride
CAS Number57-37-4
Synonym ######## α-羟基-α-苯基苯乙酸 2-(二乙氨基)乙酯 2-(二乙氨基)乙基二苯乙醇酸酯 盐酸盐 胃复康 2-(DIETHYLAMINO)ETHYL BENZILATE HYDROCHLORIDE 2-(diethylamino)-ethanobenzilatehydrochloride 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid 2-DIETHYLAMINOETHYL DIPHENYLGLYCOLATE HYDROCHLORIDE 2-Diethylaminoethyl 2-hydroxy-2,2-diphenylacetate hydrochloride 2-diethylaminoethylesterkyselinybenzilovehydrochlorid AY 5406-1 AY-5406 Aktozin Amisyl Amitakon Amizil Amizyl Arkadin BENACTIZINE HCL BENACTYZINE HYDROCHLORIDE BENZILIC ACID 2-(DIETHYLAMINO)ETHYL ESTER HYDROCHLORIDE BENZILIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE Benactyzin Benactyzine Benactyzine chloride Benactyzine hydro
MDL NumberMFCD00012624
PubChem Substance ID66448
EC Number200-324-4
Reaxys-RN3920541
Merck Number1029
Chemical Name Translation2-(二乙氨基)乙基-2-羟基-2,2-二苯基乙酸酯盐酸盐
Wiswesser Line NotationQXR&R&VO2N2&2 &GH
LabNetwork Molecule IDLN00244451
InChIInChI=1S/C20H25NO3.ClH/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,3-4,15-16H2,1-2H3;1H
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Building Blocks, C12 to C63, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks

产品应用

  • Benactyzine is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine is used as an antispasmodic.

相关文献及参考

  • Fournier, P., et al.: Therapie, 17, 1245 (1962),
  • Kosmachev, A., et al.: J. Neurochem., 71, 21 (1998),
  • Mayorga, J., et al.: Brain Res., 829, 180 (1999),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352
  • P304+P340
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
RTECSDD2800000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
UN Number UN 2811 6.1/PG 3 2811
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS

TYPE OF TEST            : LD50 -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,363,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   11,405,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehl

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 1959-76.  For
   publisher information, see PSCHDL.  Volume(issue)/page/year: 10,44,1966

其他信息

  • 储运特性:通风低温干燥; 与库房食品原料分开存放
  • TCI Shanghai:盐酸贝那替嗪 Benactyzine Hydrochloride,>;98.0%(T)(57-37-4)
  • 方法一:由二苯乙醇酸与1-氯-2二乙氨基乙烷反应得到。将甲苯、二苯乙醇酸和1-氯-2-二乙氨基乙烷在反应锅内加热回流3h,冷却结晶,甩滤得到的粗品经精制即为该品。
  • 上游原料:乙胺 --> 二苯基乙醇酸
  • 毒性分级:高毒
  • 用途一:抗胆碱药。
  • 图谱信息:乙胺痉平 (57-37-4)红外图谱(IR1) 乙胺痉平 (57-37-4)红外图谱(IR2) 乙胺痉平 (57-37-4)核磁图( 13 CNMR) 乙胺痉平 (57-37-4)核磁图( 1 HNMR) 乙胺痉平 (57-37-4)质谱(MS) 乙胺痉平 (57-37-4)Raman光谱
  • 急性毒性:口服-大鼠 LD50; 184 毫克/公斤; 口服-小鼠 LD50: 160 毫克/公斤
  • MOL 文件:57-37-4.mol
  • 可燃性危险特性:燃烧产生有毒氮氧化物和氯化氢烟雾;极少量服用则精神失常
  • Sigma Aldrich:57-37-4(sigmaaldrich)
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品

系列性分类


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