4-Dimethylaminoantipyrine 阿洛巴比妥(精神药品，不能销售)

CAS 58-15-1 MFCD00003142

化学结构图

58-15-1
SMILES: Cc1c(N(C)C)c(=O)n(-c2ccccc2)n1C

化学属性

Mol. FormulaC13H17N3O
Mol. Weight231.29
Melting Point107-109 °C(lit.)
TSCAYes
Solubility5.55 G/100 ML
Appearance 白色叶状结晶或结晶性粉末。无气味，味微苦。在空气中稳定，但在日光下会变质，当有水分时，易与弱氧化剂起化学反应。易溶于醇、氯仿、苯和乙醚，能溶于水。在水中的溶解度随苯甲酸钠的加入而增加。水溶液对石蕊呈弱碱性。熔点为107-109℃。
Density1.17
Stability对光敏感

别名和识别编码

Chemical Name4-Dimethylamino Antipyrine
Synonym (Di (Dimethylamino)phenazone 1,5-Dimethyl-4-dimethylamino 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone 1-Ph 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one 1-苯基-2,3-二甲基-4-二甲胺基吡唑酮-5 2,3 3-Pyrazolin-5-one, 4-(dimethylamino)-2,3-dimethyl-1-phenyl- 3-keto-1,5-Dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole 3-二甲基-4-二甲胺基吡唑酮-5,匹拉米洞,匹拉米董,二甲氨基安替比林,4-二甲氨基-1,5-二甲基-2-苯基-3-吡唑啉酮,4-二甲氧基安替比林 3-二甲基-4-二甲胺基吡唑酮-5;匹拉米洞;匹拉米董;二甲氨基安替比林;4-二甲氨基-1,5-二甲基-2-苯基-3-吡唑啉酮;4-二甲氧基安替比林;4-二甲氨基-2,3-二甲氧-1-苯基吡唑-5-酮 4-(DIMETHYLAMINO)-1,5-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-DIMET 4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYLPYRAZOL-5-ONE 4-N,N-Dimethylaminoantipyrine 4-dimethylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 4-dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 4-二甲基氨基-2,3-二甲氧-1-苯吡唑-1-酮 4-二甲基氨基安替比林 4-二甲基氨基安替比林/氨基比林 4-二甲氧基安替比林 4-二甲氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-二甲氨基-2,3-二甲氧-1-苯基吡唑-5-酮, 98+% AMINOPHENAZONE AMINOPYRINE Amidazophen Amidazophene Amidopyrazoline Aminophenazon Aminophenazone Aminopyrine Anafebrina Dimapyrin Dimethylaminoazophene Dimethylaminophenyldimethylpyrazolone Dipirin Dipyrine Eufibron Febrinina Febron Piramidon Piramidone Piromidina Polinalin Pyramidon {} {Chemica {} {} { {} {} {C {} {} {Chemical {} {} {uni_hambur 二甲氨基安替比林 {A
MDL NumberMFCD00003142
CAS Number58-15-1
EC Number200-365-8
Merck Number14,474
PubChem Substance ID6009
Chemical Name Translation阿洛巴比妥(精神药品，不能销售)
Wiswesser Line NotationT5NNVJ A1 BR& DN1&1 E1
InChIInChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 5ring; 6ring; amide; lactame; 1fragment

产品应用

  • 氨基比林还可作分析试剂，检定锑、铋、溴、镉、氯、钴、酮、氰化物、金、铁碘酸、铅、镍、硝酸、亚硝酸盐、锇、氮的氧化物、钯、铂、银和锌。

相关文献及参考

  • Short: II/27B
  • Short: EINECS
  • Short: III/10a
  • Merck:14,474
  • Merck:14,474 Beilstein: 25,452

安全信息

RTECSCD2625000
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Packing GroupIII
UN Number UN 2811 6.1/PG 3 UN2811
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
Storage condition 密封避光保存 Air & Light Sensitive
Hazard Codes Xn
WGK Germany3
GHS Symbol
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Class6.1 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 mg/kg/2.5Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 49,220,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 18,46,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 910 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 84,351,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 51,183,1988

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent ki

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2520 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1250 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 31 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,33,1979

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise spe

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   IAPUDO IARC Publications.  (WHO Publications Centre USA, 49 Sheridan Ave.,
   Albany, NY 12210) No.27-    1979-  Volume(issue)/page/year: 41,585,1982

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 3 mmol/L
REFERENCE :
   HDSKEK Hiroshima Daigaku Sogo Kagakubu Kiyo, 4: Kiso, Kankyo Kagaku Kenkyu.
   Bulletin of the Faculty of Integrated Arts and Sciences, Hiroshima
   University, Series 4: Fundamental and Environmental Sciences.  (1-1-89
   Higashisenda-machi, Naka-ku, Hiroshima 730, Japan)  V.6-    1980-
   Volume(issue)/page/year: 10,63,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   SKNEA7 Shionogi Kenkyusho Nenpo.  Annual Report of Shionogi Research
   Laboratory.  (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku,
   Osaka 553, Japan)  No.1-    1951-  Volume(issue)/page/year: 22,109,1972

TYPE OF TEST            : TDLo - Lowest published toxi

Restrict 精麻类化学品

其他信息

  • 用途一:用作分析试剂，也用于制药工业
  • 方法一:由氨基安替比林经催化氢化（烃化）而得。溶解罐中先加水，加热至50-60℃，搅拌下投入氨基安替比林，全溶后倒入氢化罐中。用水洗涤溶解罐，与镍催化剂搅匀再加至氢化罐。将氢化罐抽真空，然后关闭真空阀，通入氢气，开动搅拌，待压力升至0.245MPa时，停止通氢。加入甲醛，继续通入氢气。加甲醛的速度以每加5L甲醛吸氢1.8-2立方米为标准，反应温度控制在60-85℃，甲醛加完后继续反应10min，测试终点。合格后压滤，滤液冷至25℃以下，析出结晶，甩滤得氨基比林粗品。将氨基比林粗品、乙醇、活性炭升温至75-80℃，搅拌脱色1h，压滤。滤液冷至10℃，析出结晶，甩滤，用乙醇洗涤，经气流干燥，得氨基比林。
  • Acros Organics:4-二甲基氨基安替比林 4-Dimethylaminoantipyrine, 97%(58-15-1)
  • 上游原料:乙醇 --> 甲醛 --> 硫酸二甲酯 --> 焦亚硫酸钠 --> 4-氨基安替比林
  • 图谱信息:氨基比林(58-15-1)红外图谱(IR2) 氨基比林(58-15-1)质谱(MS) 氨基比林(58-15-1)核磁图( 1 HNMR) 氨基比林(58-15-1)红外图谱(IR1)
  • Sigma Aldrich:58-15-1(sigmaaldrich)
  • Alfa Aesar:4-二甲氨基-2,3-二甲氧-1-苯基吡唑-5-酮,97% 4-(Dimethylamino)antipyrine, 98+%(58-15-1)
  • 氨基比林价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30010226 氨基比林;匹拉米洞;匹拉米董;二甲氨基安替比林;4-二甲氨基-1,5-二甲基-2-苯基-3-吡唑啉酮;4-二甲氨基安替比林 100g 22元 2010/06/21 115740050 氨基比林 4-Dimethylaminoantipyrine 97% 5 GR 228元 2010/06/21 115741000 氨基比林 4-Dimethylaminoantipyrine 97% 100 GR 1470元
  • 敏感性:Air & Light Sensitive
  • 用途二:解热镇痛药，用于发热、头痛、关节痛、神经痛、痛经及活动性风湿症等。氨基比林属吡唑酮类非甾抗炎药，具有较强的解热镇痛、抗炎及抗风湿作作。但由于不良的反应严重，如粒细胞缺乏症、再生障碍性贫血等。因此在临床上的应用已日益减少，逐渐趋向淘汰。氨基比林还可作分析试剂，检定锑、铋、溴、镉、氯、钴、酮、氰化物、金、铁碘酸、铅、镍、硝酸、亚硝酸盐、锇、氮的氧化物、钯、铂、银和锌。
  • 无气味，味微苦。在空气中稳定，但在日光下会变质，当有水分时，易与弱氧化剂起化学反应。易溶于醇、氯仿、苯和乙醚，能溶于水。在水中的溶解度随苯甲酸钠的加入而增加。水溶液对石蕊呈弱碱性。
  • MSDS 信息:Aminophenazone(58-15-1).msds
  • 用途三:氨基比林还可作分析试剂，检定锑、铋、溴、镉、氯、钴、酮、氰化物、金、铁碘酸、铅、镍、硝酸、亚硝酸盐、锇、氮的氧化物、钯、铂、银和锌。
  • MOL 文件:58-15-1.mol

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