2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine 2-氯-10-(3-[1-甲基-4-哌嗪基]丙基)吩噻嗪

CAS 58-38-8 MFCD00056797

化学结构图

58-38-8
SMILES: CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1

化学属性

Mol. FormulaC20H24ClN3S
Mol. Weight373.98
Melting Point228 ºC

别名和识别编码

Chemical Name2-Chloro-10-(3-[1-methyl-4-piperazinyl]propyl)phenothiazine
MDL NumberMFCD00056797
EC Number200-379-4
Synonym 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)- 过二苯嗪 bayera173 6140 R.P. Meterazine 3-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine Kronocin 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin 甲哌氯丙嗪 SKF 4657 chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine Temetid Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine Bayer A 173 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]- 6140 RP PROCHLORPERAZINE 丙氯拉嗪 chloro-3(n-methylpiperazinyl-3propyl)-10phenothiazine(french) Prochlorperazine Nipodal Prochlorpromazine Stemetil 4-[3-(2氯吩噻嗪-10-基)丙基]-1-呱嗪乙醇 6140rp 2-Chloro-10-(3-(1-methyl-4-piperazinyl)-propyl)-phenothiazine Emelent 氯吩嗪 N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine Capazine Tementil 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazin Chlormeprazine 奋乃静 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine Chlorperazine 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
CAS Number58-38-8
Chemical Name Translation2-氯-10-(3-[1-甲基-4-哌嗪基]丙基)吩噻嗪
Wiswesser Line NotationT C666 BN ISJ EG B3- AT6N DNTJ D1
PubChem Substance ID4917
InChIInChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
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安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSSO2700000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,213,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,213,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,213,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 16,255,1967

TYPE OF TEST

TYPE OF TEST            : TDLo - Lo

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 1-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   15QWAW "Agents Affecting Fertility, a Symposium, 1964," Austin, C.R., and
   J.S. Perry, eds., Boston, Little, Brown & Co., 1965 Volume(issue)/page/year:
   -,290,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 12,346,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CAJPBD Proceedings of the Congenital Anomalies Research Association of
   Japan.  (Kyoto, Japan) No.1-    1961-  Volume(issue)/page/year: 3,2,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20400 ug/kg
SEX/DURATION            : female 51 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 195

其他信息

  • MOL 文件:58-38-8.mol
  • MSDS 信息:2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine(58-38-8).msds
  • 下游产品:奋乃静

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