N-Methylpiperidine N-甲基哌啶

CAS 626-67-5 MFCD00006491

化学结构图

626-67-5
SMILES: CN1CCCCC1

化学属性

Mol. FormulaC6H13N
Mol. Weight99
Density0.816
Refractive index1.4360 to 1.4380
Flash Point3°C
TSCAYes
Boiling Point106-107
Melting Point-50°C
Solubilitymiscible

别名和识别编码

Chemical NameN-Methylpiperidine
Synonym 1-METHYLPIPERIDINE 98+% 1-METHYLPIPERIDINE SOLUTION, FOR PROT.SE Q. ANAL., 40 ML 1-Methylpiperidine 1-Methylpiperidine,97% 1-Pipecoline 1-methylpiperidine N-Methylpiperidine N-methylpiperidine N-methylpiperidine hydrochloride NMPPR {} {} {} {} {} {} {uni_hamburg}
MDL NumberMFCD00006491
CAS Number626-67-5
EC Number210-959-9
Beilstein Registry Number20,16
PubChem Substance ID12291
Chemical Name TranslationN-甲基哌啶
Reaxys-RN1073
Wiswesser Line NotationT6NTJ A1
InChIKeyPAMIQIKDUOTOBW-UHFFFAOYSA-N
LabNetwork Molecule IDLN00010857
InChIInChI=1S/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines
  • {SNA} A-D, Alphabetical Listings, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products, M-N
  • {Chemicalbook} 农药中间体: 植物生长调节剂中间体
  • {SNA} Molecular Biology, Protein Sequencing, Protein Structural Analysis, Proteomics, Reagents for Protein Sequencing
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; 1fragment
  • {SNA} Protein Sequencing, Protein Structural Analysis, Proteomics, Reagents for Protein Sequencing
  • {SNA} Protein Sequencing, Protein Structural Analysis, Reagents for Protein Sequencing, 分子生物学, 蛋白质组学

产品应用

  • Reactant for:
  • ·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
  • ·One-pot synthesis of Z-cinnamic acids
  • Reactant for synthesis of:
  • ·Unsymmetrical ureas
  • ·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
  • ·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
  • ·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases

相关文献及参考

  • Short: III/20a
  • Beilstein:20,16
  • Short: III/35D3
  • Short: III/20c

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
Risk Statements
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTN1225000
Packing GroupII
UN Number 2399 UN2399
Hazard Codes 3 C F,T
Hazard Class3/8
Storage condition -20°C
Warnings 危化品目录(2015) 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BDCGAS Berichte der Deutschen Chemischen Gesellschaft.  (Leipzig, Ger. Dem.
   Rep.)  V.1-61, 1868-1928. For publisher information, see CHBEAM.
   Volume(issue)/page/year: 34,2408,1901

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 86,1325,1978

Restrict 危险品

其他信息

  • N-甲基哌啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0403 1-甲基哌啶 1-Methylpiperidine 500ML 993元 2014/06/02 M0403 1-甲基哌啶 1-Methylpiperidine 25ML 137元 2010/06/21 127482500 N-甲基哌啶 N-Methylpiperidine 99% 250 ML 756元
  • MSDS 信息:N-甲基哌啶(626-67-5).msds
  • 和水混溶。溶于甲醇、乙醇、丙酮和甲苯。
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 用途三:药物和有机合成中间体。
  • MOL 文件:626-67-5.mol
  • 类别:易燃液体
  • 方法一:其制备方法是在反应釜中加入哌啶、甲醛，最后加甲酸，加热，保持温度90℃，反应6h，冷却，向混合物加入盐酸，升温加热蒸出过量甲醛和甲酸，残留物冷却，加入氢氧化钠，升温蒸出1-甲基哌啶和水混合物，此混合物经固体氢氧化钠干燥，放到蒸馏釜中蒸馏得产品。
  • 急性毒性:腹腔-小鼠 LD50: 400 毫克/ 公斤; 皮下- 兔子 LDL0: 300 毫克/ 公斤
  • Acros Organics:N-甲基哌啶 N-Methylpiperidine, 99%(626-67-5)
  • 用途一:用作药物和有机合成中间体
  • F:3-10
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生有毒氮氧化物烟雾
  • Alfa Aesar:1-甲基哌啶,97% 1-Methylpiperidine, 99%(626-67-5)
  • 上游原料:固体氢氧化钠
  • Sigma Aldrich:626-67-5(sigmaaldrich)
  • 毒性分级:高毒
  • 用途二:1-甲基哌啶是植物生长调节剂甲哌鎓的中间体。
  • 图谱信息:N-甲基哌啶(626-67-5)核磁图( 1 HNMR) N-甲基哌啶(626-67-5)核磁图( 13 CNMR) N-甲基哌啶(626-67-5)质谱(MS) N-甲基哌啶(626-67-5)红外图谱(IR1)
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 外观性质:无色液体。
  • 海关编码:29333999
  • TCI Shanghai:1-甲基哌啶 1-Methylpiperidine,>;99.0%(GC)(626-67-5)
  • 下游产品:缩节胺

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Homopiperidines 同哌啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperidines 哌啶
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Sequencing - Protein Structural Analysis
  5. Reagents for Protein Sequencing - Protein Sequencing

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