2',5'-Dideoxyadenosine (2R,3S,5R)-5-(6-氨基-9H-嘌呤-9-基)-2-甲基四氢呋喃-3-醇

CAS 6698-26-6 MFCD00210904

化学结构图

6698-26-6
SMILES: C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O

化学属性

Mol. FormulaC10H13N5O2
Mol. Weight235.24
Density1.422
Boiling Point547.0±60.0 °C at 760 mmHg

别名和识别编码

Chemical Name(2R,3S,5R)-5-(6-Amino-9H-Purin-9-Yl)-2-Methyltetrahydrofuran-3-Ol
MDL NumberMFCD00210904
PubChem Substance ID65166
CAS Number6698-26-6
EC Number250-023-7
Beilstein Registry Number2384789
Synonym 2',5'-Dideoxyadenosine {LY} 2',5'-Dideoxyadenosine 2',5'-dideoxyadenosine {} {LY} 2',5'-Dideoxyadenosine {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',5'-Dideoxyadenos
Chemical Name Translation(2R,3S,5R)-5-(6-氨基-9H-嘌呤-9-基)-2-甲基四氢呋喃-3-醇
LabNetwork Molecule IDLN01330992
InChIInChI=1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
Canonical SMILESC[C@@H]1[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
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分类

  • {SNA} A to C, Adenylate cyclase, Adenylyl Cyclase Inhibitors, Biochemicals and Reagents, Cyclic Nucleotide Metabolism, D-DIF, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G Proteins and Cyclic Nucleotides, 生物活性小分子, 细胞信号转导和神经科学,

相关文献及参考

  • [2]. Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8.
  • [3]. Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631.
  • [4]. Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.
  • Bodenstine, T.M., et al., Homotypic Gap Junctional Communication Associated With Metastasis Suppression Increases With PKA Activity And Is Unaffected By PI3K Inhibition. Cancer Res. 70 , 10002-11, (2010) 摘要
  • Chen, M.C., et al., Involvement Of CAMP In Nerve Growth Factor-triggered P35/Cdk5 Activation And Differentiation In PC12 Cells. Am. J. Physiol. Cell Physiol. 299

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition 2-8°C {LY} 2-8°C 2-8°C, protect from light {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Adenylate cyclase - A to C
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Adenylyl Cyclase Inhibitors - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Deoxynucleosides&Deoxynucleotides and their Analogs
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenylate Cyclase  (腺苷酸环化酶)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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