• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
• {SNA} Conditioned Media, Media Supplements and Reagents, Hybridoma Reagents, 细胞培养, 试剂和添加剂
• {SNA} Nucleoside Analogs, 核苷，核苷酸和寡核苷酸, 生化试剂
• {SA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, N
• Heterocycles
• {SNA} Cell Culture, Conditioned Media, Media Supplements and Reagents, Hybridoma Reagents, Reagents and Supplements
• {SNA} Analytical Standards, EP Standards, EP Standards C - D,
• {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
• {uni_hamburg} no charge; nitrogen heterocycle; aromatic; large ring; fused rings; 5ring;

产品应用

• 生化试剂，制备生物培养基。

相关文献及参考

• Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),
• Merck: 14,4869
• Merck: 14,4869 Beilstein:26,416
• Short: III/20a
• Short: III/31a
• [1]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 gm/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

其他信息

• 方法一:氰乙酸乙酯与乙醇钠、硫脲经环合反应得到2-巯基-4-氨基-6-羟基嘧啶，再经亚硝化、还原、消除、环合，制得6-羟基嘌呤。
• 下游产品:腺嘌呤 --> 阿昔洛韦 --> 6-巯基嘌呤 --> 6-苄胺基嘌呤 --> 6-氰嘌呤 --> 6-溴嘌呤 --> 6-苄氨基嘌呤 --> 6-碘嘌呤 --> 6-二甲基氨基嘌呤 --> 6-巯基嘌呤(一水合物)
• MSDS 信息:6-Hydroxypurine(68-94-0).msds
• 6-羟基嘌呤价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65009631 次黄嘌呤（+4℃） 1g 44.7元 2011/08/23 SH963601 次黄嘌呤;次黄碱;6-氧嘌呤;6-羟基嘌呤 1g 216元 2011/04/16 H0311 次黄嘌呤 Hypoxanthine 25G 582元
• 外观性质:无色针状结晶。100ml水19℃时溶解0.07g，100℃时溶解1.4g。溶于稀酸和稀碱。在150℃时分解而不熔融。pH4～7时最大吸收波长249.5mn。ε 10700。最小吸收波长221nm。吸光度比值A250/A260=1.32，A280/A260=0.09,A290/A260=0.01。半数致死量(小鼠,腹腔)750mg/kg。熔点：250℃
• Hazard Note:Harmful
• Sigma Aldrich:68-94-0(sigmaaldrich)
• 上游原料:氰乙酸乙酯 --> 硫脲 --> 乙醇钠 --> 6-氨基-2-硫脲嘧啶
• 100ml水19℃时溶解0.07g，100℃时溶解1.4g。溶于稀酸和稀碱。在150℃时分解而不熔融。pH4～7时最大吸收波长249.5mn。ε 10700。最小吸收波长221nm。吸光度比值A250/A260=1.32，A280/A260=0.09,A290/A260=0.01。半数致死量(小鼠,腹腔)750mg/kg。
• MOL 文件:68-94-0.mol
• Acros Organics:次黄嘌呤 Hypoxanthine, 99.5%(68-94-0)
• 用途二:用作巯嘌呤和硫唑嘌呤的原料
• 用途三:生化试剂，制备生物培养基。
• Alfa Aesar:次黄嘌呤,99% Hypoxanthine, 99%(68-94-0)
• TCI Shanghai:次黄嘌呤 Hypoxanthine,>;98.0%(LC)(E)(68-94-0)
• 用途一:抗恶性肿瘤药6-巯嘌呤的中间体。