2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-

CAS 70-22-4 MFCD00003200

化学结构图

70-22-4
SMILES: O=C1CCCN1CC#CCN1CCCC1

化学属性

Mol. FormulaC12H18N2O
Mol. Weight206.32
Refractive indexn20/D 1.517(lit.)
Density1 g/mL at 25 °C(lit.)
Boiling Point124 °C/0.1 mmHg(lit.)

别名和识别编码

Chemical Name2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-
Synonym 2'-Oxopyrrolidino-1-pyrrolidino-4-butyne 1-(4-(1-Pyrrolidinyl)-2-butynyl)-2-pyrrolidinone Oxytremorine Oxotremorin 1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone Oxotremorine
EC Number200-728-0
Beilstein Registry Number1530948
MDL NumberMFCD00003200
Wiswesser Line NotationT5NVTJ A2UU2- AT5NTJ
CAS Number70-22-4
PubChem Substance ID4630
InChIInChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
LabNetwork Molecule IDLN04690861
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安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUY5950100
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 162 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 57,1543,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HPFSDS HHS Publication (FDA. United States).  (U.S. Government Printing
   Office, Supt. of Documents, Washington, DC 20402)  1980-
   Volume(issue)/page/year: FDA-80-1076,212,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : R

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year: 29,39,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/y

系列性分类

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