6-Methyl-4-nitroquinoline 1-oxide

CAS 715-48-0 MFCD01685464

化学结构图

715-48-0
SMILES: Cc1ccc2c(c1)c([N+](=O)[O-])cc[n+]2[O-]

化学属性

Mol. FormulaC10H8N2O3
Mol. Weight204.20

别名和识别编码

Chemical NameQuinoline, 6-methyl-4-nitro-, 1-oxide
InChIKeyVJJJEAZZHWTTED-UHFFFAOYSA-N
Wiswesser Line NotationT66 BNJ BO ENW H1
Synonym 6-Methyl-4-nitroquinoline 1-oxide
CAS Number715-48-0
Beilstein Registry Number0187028
PubChem Substance ID91483
InChIInChI=1S/C10H8N2O3/c1-7-2-3-9-8(6-7)10(12(14)15)4-5-11(9)13/h2-6H,1H3
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg/50D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   16,631,1967

RTECSVC1225000
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   13,285,1964

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 8 umol/L
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 31,959,1983

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Ascites tumor
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   17,31,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 2500 nmol/L
REFERENCE :
   PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
   Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
   Tokyo 113, Japan)  1st-    1971-  Volume(issue)/page/year: 2,17,1972

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 4800 ug/L
REFERENCE :
   EXPEAM Experie

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 17,765,1976

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 73 umol/L
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   60,155,1969

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