Acetyl chloride 乙酰氯

CAS 75-36-5 MFCD00000719

化学结构图

75-36-5
SMILES: CC(=O)Cl

化学属性

Mol. FormulaC2H3ClO
Mol. Weight78.5
Refractive indexn20/D 1.423
Boiling Point52
Density1.104
Melting Point-112
Flash Point5°C(lit.)
TSCAYes
Autoignition Point1353 °F
Vapor Density2.7 (vs air)
Vapor Pressure11.69 psi ( 20 °C)
SolubilityMiscible with benzene, chloroform, ether
Stability对热敏感，湿度敏感
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameAcetyl chloride
CAS Number75-36-5
PubChem Substance ID6367
EC Number200-865-6
Beilstein Registry Number605303
MDL NumberMFCD00000719
Synonym ACETYL CHLORIDE ACETYL CHLORIDE, REAGENTPLUS, >=99% ACETYL CHLORIDE, REAGENTPLUS, >=99% AKOS BBS-00003929 Acetic acid chloride; Acetic chloride Acetic acid monochloride Acetic chloride Acetyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Reaxys-RN605303
Merck Number85
Chemical Name Translation乙酰氯
Wiswesser Line NotationGV1
LabNetwork Molecule IDLN00164431
InChIInChI=1S/C2H3ClO/c1-2(3)4/h1H3
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分类

  • {SNA} A-B, Puriss p.a., Analytical Reagents for General Use, Puriss p.a., 分析/色谱, 分析试剂
  • {SNA} Essential Chemicals, Inorganic Salts, Solutions and Reagents, Reagent Grade, Research Essentials
  • {SA} A-B, Puriss p.a., Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography, Puriss p.a.
  • {uni_hamburg} no charge

产品应用

  • 测定胆固醇及有机液体中的水分、测定羟基四乙基铅等，鉴定亚硝基。用作乙酰化试剂。用于制药的染料合成。

相关文献及参考

  • Merck: 14,85
  • {uni_hambu
  • Merck: 14,85 Beilstein:2(4)395
  • Short: II/24B

安全信息

GHS Symbol
WGK Germany1
Hazard Codes 3 F,C
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H351 Suspected of causing cancer 怀疑致癌
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSAO6390000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S1/2 None 上锁保管并避免儿童触及；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R14 Reacts violently with water 遇水会猛烈反应
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number 1717
Storage condition +4°C 0-10 0-10°C 4 4℃ Moisture Sensitive Store at RT 充氩气保存;储存温度2-8°C 易挥发，对湿度敏感。
Packing GroupII
Hazard Class3/8
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 910 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 32(3),48,1988

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 2 ppm/1M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National
   Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year: 2,28,1961

Restrict -

其他信息

  • 图谱信息:乙酰氯(75-36-5)核磁图( 13 CNMR) 乙酰氯(75-36-5)红外图谱(IR1) 乙酰氯(75-36-5)质谱(MS) 乙酰氯(75-36-5)核磁图( 1 HNMR)
  • Sigma Aldrich:75-36-5(sigmaaldrich)
  • 有害影响和中毒症状:乙酰氯是一种刺激物和腐蚀剂。接触皮肤能引起灼伤，蒸气强烈刺激眼和粘膜。人吸入2ppm，便能感到刺激作用。短期暴露于较高浓度乙酰氯中，可能引起死亡或永久性损伤。水生动物中毒量估计在10～100ppm的范围。
  • 防护措施:本品极强烈地刺激眼、皮肤、粘膜，产生严重烧伤。车间应有良好的通风，设备应密闭。操作人员须穿戴防护服、眼镜及橡皮手套。
  • 用途一:用于有机合成、染料及医药等工业
  • 乙酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80000928 氯乙酰¤ 500ml 44元 2011/04/16 A0082 乙酰氯 Acetyl Chloride 100G 197元 2011/04/16 A0082 乙酰氯 Acetyl Chloride 500G 582元
  • 用途四:为农药和医药的原料，还是制造水处理剂亚乙基二磷酸的中间体，也用于制造新型电镀络合剂。乙酰氯是重要的乙酰化试剂，酰化能力比乙酐强，广泛用于有机
  • Acros Organics:乙酰氯 Acetyl
  • 下游产品:2-氢硫基-4-羟基-6-甲基嘧啶 --> 4-溴-2-氯乙酰苯胺 --> 4-溴-3-氯乙酰苯胺 --> 1,4-萘二甲酸 --> 4'-溴-2'-甲基乙酰苯胺 --> 2-乙酰-3-溴噻吩 --> 乙酰扁桃酰氯 --> 羊毛防缩整理剂 W-G3 --> 乙酰唑胺 --> alpha-(三氯甲基)苄基醇乙酸酯 --> 2-乙酰-3-氯噻吩 --> 2-羟基-5-甲基苯乙酮 --> 2,4-二氯苯乙酮 --> 1,1,1-三氯丙酮 --> 氯化乙酰胆碱 --> 5-乙酰基-2,3-二氢苯并[B]呋喃 --> 2-甲基-2-噻唑啉 --> 联苯单乙酮 --> 3-甲基-3-[4-(2-甲基丙基)苯基]环氧乙烷羧酸乙酯 --> 4-(4-氯苯氧基)-2′-氯苯乙酮 --> 4-(三氟甲氧基)苯乙酮 --> 4,4'-二乙酰联苯 --> 二乙二醇丁醚醋酸酯 --> 3-乙酰硫茚 --> 3-氯-4-氟苯乙酮 --> 乙酰氧基乙酰氯 --> 1-(3-甲基-2,4-二氯苯基)乙酮 --> 5-乙酰基水杨酰胺 --> 乙酰托品酰氯 --> 2-乙酰基-5-氯噻酚 --> 1,1'-二乙酰基二茂铁 --> N
  • F:3
  • 方法一:工业上，乙酰氯可由乙烯配氯化氢反应，或由乙酸钠，二氧化硫与氯反应制得。实验室可由乙酸，乙酸钠或乙酐与各种氯化剂反应制得。例如乙酐与氯磺酸(或氯化氢,四氯化碳,光气)反应得到。也可用冰醋酸与苯甲酰氯(或四氯化硅，三氯化磷，氯化亚硫酸，五氯化磷，)反应得到。操作实例1：配料比(摩尔比)为冰醋酸：三氯化磷=3：1.2。将冰醋酸加入反应器，缓慢搅拌，于室温下在10-15min内滴加三氯化磷。加热升温，保持40-50℃反应0.5h，反应产物静置，分离即得乙酰氯粗品，纯收率70%左右。操作实例2 在3L三口烧瓶中，放入360g(6mol)冰醋酸和552g甲苯，加热至50℃于30min内滴加510g(3mol)四氯化硅，并在50℃保温至氯化氢气体不再急剧逸出为止。再进行分馏，蒸至柱顶温度80-85℃为止得粗品。精品再蒸馏，取50-65馏分，得乙酰氯400g，产率85%。原料消耗定额：冰醋酸850kg/t、三氯化磷1950kg/t。
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 高热分解有毒光气; 遇水放出有毒氯化物烟雾
  • 主要用途:乙酰氯是最常用的乙酰化试剂，与醇、酚作用得到乙酸酯，与氨作用形成乙酰胺，与伯胺、仲胺作用生成N-取代乙酰胺。 用于制药工业，农
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • Alfa Aesar:氯乙酰,99+% Acetyl chloride, 99+%(75-36-5)
  • 上游原料:乙酸 --> 四氯化碳 --> 三氯化磷

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  1. Research Essentials 基础科研
  2. Essential Chemicals - Research Essentials
  3. Inorganic Salts, Solutions and Reagents - Essential Chemicals
  4. Reagent Grade - Inorganic Salts, Solutions and Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Aryl 芳基卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  5. Alkyl 烷基卤代烃
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  5. A-B, Puriss p.a. - Puriss p.a.
  1. Analytical & Chromatography 分析化学与色谱
  2. Adsorbents, Filter Aids and Drying Agents
  3. Other Drying Agents
  1. Acyl halide
  2. acyl chloride

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