Pentobarbitone 戊巴比妥溶液,100ppm

CAS 76-74-4 MFCD00057561

化学结构图

76-74-4
SMILES: CCCC(C)C1(CC)C(=O)NC(=O)NC1=O

化学属性

Mol. FormulaC11H18N2O3
Mol. Weight226.31
Melting Point129.5 ºC
Solubility679 MG/L

别名和识别编码

Chemical NamePentobarbitone
Synonym Rivadorm Pentabarbitone 5-ethyl-5-(1-methylbutyl)barbituric acid component of Emesert 5-Ethyl-5-(1-methylbutyl)barbituric acidcid 5-ethyl-5-(1-methylbutyl)-barbituricaci Pentobarbiturate Pentobarbital Barbituric acid, 5-ethyl-5-(1-methylbutyl)- 5-乙基-5-(1-甲基丁基)-2,4,6-(1H,3H,5H)-嘧啶三酮 Neodorm (new) 5-Ethyl-5-(1-methylbutyl)barbituric acid 戊巴比妥 Pentobarbitone Pentobarbital; 5-Ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione; 5-Ethyl-5-(1-methylbutyl)barbituric acid Ethyl-propylmethylcarbinylbarbituric acid Nembutal pentobarbitone Neodorm PENTOBARBITAL 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione 6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-4 Dorsital 5-Ethyl-5-(sec-pentyl)barbituric acid 5-Ethyl-5-(1-methylbutyl)-2,4,6-trioxohexahydropyrimidine Nembutal Pentobarbituric acid Mebubarbital 5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione barbituricacid,5-ethyl-5-(2-pentyl) 5-Ethyl-5-(1-methylbutyl)malonylurea 5-ethyl-5-(sec-pentyl)barbituricacid Ethaminal ethyl-propylmethylcarbinylbarbituricacid 5-乙基-5-(1-甲基丁基)巴比妥酸 5-ETHYL-5-[1-METHYLBUTYL]-2,4,6-TRIOXOHEXAHYDROPYRIMIDINE 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-
MDL NumberMFCD00057561
EC Number200-983-8
CAS Number76-74-4
Chemical Name Translation戊巴比妥溶液,100ppm
Wiswesser Line NotationT6VMVMV FHJ FY3&1 F2
Beilstein Registry Number0087067
PubChem Substance ID4737
InChIInChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
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安全信息

GHS Symbol
WGK Germany1
Precautionary statements
  • P301+P310
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H301 Toxic if swallowed 吞食有毒
RTECSCQ5775000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing GroupIII
Hazard Codes T,F
Hazard Class6.1(b)
Storage condition 2-8°C
UN Number UN 2811 6.1/PG 3
Safety Statements
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R11 Highly flammable 非常易燃
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R25 Toxic if swallowed 吞咽有毒
Restrict {} 精神药品 精麻类化学品
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 108 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHMGBN Pharmacology: International Journal of Experimental and Clinical
   Pharmacology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland)  V.1-
   1968-  Volume(issue)/page/year: 19,182,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 181,68,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 141,83,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 96,209,1949

TYPE OF T

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 1200 ug/kg
SEX/DURATION            : male 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - other effects on male
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   DEPBA5 Developmental Psychobiology.  (John Wiley & Sons, Inc., 605 Third
   Ave., New York, NY 10158) V.1-    1968-  Volume(issue)/page/year: 12,49,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 100 mg/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - oogenesis
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 24(1),19A,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 35 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstr

其他信息

  • Sigma Aldrich:76-74-4(sigmaaldrich)
  • MOL 文件:76-74-4.mol
  • MSDS 信息:5-Ethyl-5-(1-methylbutyl)barbituric acid(76-74-4).msds

系列性分类


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