6-Methoxy-8-nitroquinoline 6-甲氧基-8-硝基喹啉

CAS 85-81-4 MFCD00006802

化学结构图

85-81-4
SMILES: COc1cc([N+](=O)[O-])c2ncccc2c1

化学属性

Mol. FormulaC10H8N2O3
Mol. Weight204.18
Melting Point158-160°C
Appearance 黄色针状结晶。熔点159-160℃。溶于氯仿。
Boiling Point342.67 °C at 760 mmHg

别名和识别编码

Chemical Name6-Methoxy-8-nitroquinoline
CAS Number85-81-4
Synonym 6-Methoxy-8-nitroquinoline {LY} 6-Methoxy-8-nitroquinoline {} {LY} 6-Methoxy-8-nitroquinoline {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Methoxy-8-nitroquinoline {} {} {} {} {}
MDL NumberMFCD00006802
EC Number201-633-7
PubChem Substance ID6822
Reaxys-RN168992
Beilstein Registry Number168992
Chemical Name Translation6-甲氧基-8-硝基喹啉
Wiswesser Line NotationT66 BNJ HO1 JNW
LabNetwork Molecule IDLN00224490
Canonical SMILESO=[N+](C1=C2N=CC=CC2=CC(OC)=C1)[O-]
InChIInChI=1S/C10H8N2O3/c1-15-8-5-7-3-2-4-11-10(7)9(6-8)12(13)14/h2-6H,1H3
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分类

  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines

安全信息

Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P302+P352
  • P302+P352+P312+P362+P364
  • P304+P312
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+
  • P305+P351+P338+P337+P313
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
RTECSVC0365000
Signal word Warning
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,11,1978

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 6-甲氧基-8-硝基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M2057 6-甲氧基-8-硝基喹啉 6-Methoxy-8-nitroquinoline 5G 1360元 2014/06/02 M2057 6-甲氧基-8-硝基喹啉 6-Methoxy-8-nitroquinoline 25G 4680元 2010/06/21 195600010 6-甲氧基-8-硝基喹啉 6-Methoxy-8-nitroquinoline 99% 1 GR 656元
  • MOL 文件:85-81-4.mol
  • Acros Organics:6-甲氧基-8-硝基喹啉 6-Methoxy-8-nitroquinoline, 99%(85-81-4)
  • 上游原料:冰染重氮组分 1
  • 图谱信息:6-甲氧基-8-硝基喹啉(85-81-4)核磁图( 1 HNMR) 6-甲氧基-8-硝基喹啉(85-81-4)红外图谱(IR2) 6-甲氧基-8-硝基喹啉(85-81-4)质谱(MS) 6-甲氧基-8-硝基喹啉(85-81-4)核磁图( 13 CNMR) 6-甲氧基-8-硝基喹啉(85-81-4)红外图谱(IR1)
  • 下游产品:8-氨基-6-甲氧基喹啉
  • 方法一:由4-甲氧基-2-硝基苯胺经环合反应而得。将甘油加入反应锅内,在70℃以下加入硫酸,再投入4-甲氧基-2-硝基苯胺。在75-80℃保温后加入碘化钾和碘的水溶液,升温至125℃,保温直至反应到达终点。用冰水稀释,在35℃以下用氢氧化钠溶液中和至pH 值为3.5,过滤,水洗至pH值为5,得6-甲氧基-8-硝基喹啉。收率为90%。
  • Sigma Aldrich:85-81-4(sigmaaldrich)
  • 用途一:该品可作抗疟药磷酸伯氨喹的中间体。

系列性分类


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