2,5-Di-tert-butylhydroquinone 2,5-二叔丁基对苯二酚

CAS 88-58-4 MFCD00008825

化学结构图

88-58-4
SMILES: CC(C)(C)c1cc(O)c(C(C)(C)C)cc1O

化学属性

Mol. FormulaC14H22O2
Mol. Weight222.32
Melting Point216-218°C
Density1.012
Flash Point>200°(392°F)
TSCAYes
Boiling Point321 °C at 760 mmHg
Autoignition Point790 °F
Appearance 白色或微黄色结晶体。熔点217-219℃。溶于乙醇、丙酮、乙酸乙酯和二硫化碳，微溶于苯、汽油、不溶于水。贮存稳定。
SolubilitySoluble in acetone, benzene, aqueous alkali, DMSO (25 mg/ml warm), and 100% ethanol.
Stability对光和空气敏感

别名和识别编码

Chemical Name2,5-Di-tert-butylhydroquinone
CAS Number88-58-4
Alfabeta NameDIBUTYLHYDROQUINONE TERT25---,
MDL NumberMFCD00008825
PubChem Substance ID87567532
EC Number201-841-8
Beilstein Registry Number6(3)4741
Reaxys-RN2049542
Synonym 2,5-Di-tert-butylhydroquinone {LY} 2,5-Di-tert-butylhydroquinone {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydroquinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Di-tert-butylhydr
Chemical Name Translation2,5-二叔丁基对苯二酚
Wiswesser Line NotationL6V DVJ BX1&1&1 EX1&1&1
LabNetwork Molecule IDLN00174481
Canonical SMILESOC1=CC(C(C)(C)C)=C(O)C=C1C(C)(C)C
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分类

  • Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Polyols
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Polyols

产品应用

  • An inducer of Ca2+

相关文献及参考

  • Beilstein:6(3)4741
  • [1]. Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xi
RTECSMX5160000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P352+P332+P313+P362+P364
Signal word
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} { 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 134 gm/kg/24W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,1341,1991

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

其他信息

  • Sigma Aldrich:88-58-4(sigmaaldrich)
  • 用途三:抗氧剂
  • 2,5-Di-tert-butylhydroquinone (DBHQ) has been shown to be a selective and potent inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which is shown to cause induction of Ca2+ release from agonist-insensitive and agonist-sensitive intracellular stores. In isolated rat hepatocyte studies, DBHQ was reported to induce a rapid increase in cytosolic Ca2+ concentration without loss of other microsomal enzyme activity, altering membrane permeability, or modification of microsomal protein thiols.
  • 不溶于水，溶于丙酮、醇和苯。实际上不溶于甲苯和己烷。
  • 2,5-二特丁基对苯二酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010225 2,5-二叔丁基对苯二酚;2,5-二叔丁基氢醌; 2,5-二第三丁基对苯二酚 100g 150元 2011/04/16 D0940 2,5-二-叔丁基对苯二酚 2,5-Di-tert-butylhydroquinone 500G 618元 2011/04/16 D0940 2,5-二-叔丁基对苯二酚 2,5-Di-tert-butylhydroquinone 25G 139元
  • 用途一:用作天然橡胶、合成橡胶及乳胶的抗氧剂
  • 海关编码:29072900
  • MSDS 信息:Dibutylhydroquinone(88-58-4).msds
  • 方法一:由对苯二酚与异丁烯反应而得。
  • TCI Shanghai:2,5-二叔丁基对苯二酚 2,5-Di-tert-butylhydroquinone,>;98.0%(GC)(88-58-4)
  • Hazard Note:Irritant
  • Acros Organics:2,5-二叔丁基对苯二酚 2,5-Di-tert-butylhydroquinone, 99%(88-58-4)
  • 图谱信息:2,5-二特丁基对苯二酚(88-58-4)质谱(MS) 2,5-二特丁基对苯二酚(88-58-4)红外图谱(IR1) 2,5-二特丁基对苯二酚(88-58-4)核磁图( 1 HNMR) 2,5-二特丁基对苯二酚(88-58-4)核磁图( 13 CNMR)
  • 下游产品:6-溴吲哚-2-甲醛 --> 6-溴吲哚-2-羧酸 --> 6-溴吲哚-2-羧酸乙酯 --> 叔丁基氢醌
  • Alfa Aesar:2,5-二-叔-丁基对苯二酚,98+% 2,5-Di-tert-butylhydroquinone, 98+%(88-58-4)
  • 上游原料:1,4-苯二酚 --> 异丁烯
  • 用途二:用作天然橡胶、合成橡胶及胶乳的抗氧剂。能延缓硫化胶及未硫化胶的氧化老化及紫外光老化，是一种不污染橡胶制品的、日光照射也不变色的无着色性、非污染性防老剂。耐氧化方面优于通常的防老剂，亦可提高橡胶制品的耐热性和耐屈挠龟裂性。有效配合量为0.5-1份。该品对胶粘剂的防老化效果亦好。容易分散，对硫化没有影响。该品宜用于制造浅色橡胶制品、医疗用品、胶乳制品和胶粘带等。亦可作为油类和合成树脂的抗氧剂。在塑料工业中可作为聚烯烃和聚甲醛的热、光稳定剂。
  • MOL 文件:88-58-4.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Polyols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols
  1. Medical Research Areas
  2. Metabolism
  3. Lipoxygenase  (脂氧合酶)

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