7-N,7-N-dimethyl-7,8-dihydro-6H-cyclopenta[e][1,3]benzothiazole-2,7-diamine;6-N,6-N-dimethyl-6,7-dihydro-5H-cyclopenta[f][1,3]benzothiazole-2,6-diamine;7-N,7-N-dimethyl-7,8-dihydro-6H-cyclopenta[g][1,3]benzothiazole-2,7-diamine;6-N,6-N-dimethyl-5,6,7,8-tetrahydrobenzo[f][1,3]benzothiazole-2,6-diamine;7-N,7-N-dimethyl-5,6,7,8-tetrahydrobenzo[f][1,3]benzothiazole-2,7-diamine 磷酸二酯酶I
CAS 9025-82-5 MFCD00131883
化学结构图
SMILES: CN(C)C1CCc2cc3nc(N)sc3cc2C1.CN(C)C1CCc2cc3sc(N)nc3cc2C1.CN(C)C1Cc2cc3nc(N)sc3cc2C1.CN(C)C1Cc2ccc3nc(N)sc3c2C1.CN(C)C1Cc2ccc3sc(N)nc3c2C1
别名和识别编码
| MDL Number | MFCD00131883 |
|---|---|
| CAS Number | 9025-82-5 |
| Synonym | 5'-Exonuclease 5'-Exonuclease Oligonucleate 5'-nucleotidohydrolase E.C. 3.1.4.1 Oligonucleate 5'-nucleotidohydrolase Phosphodiesterase I Phosphodiesterase I from Bothrops atrox 磷酸二脂酶I |
| EC Number | 232-806-5 |
| Chemical Name | Phosphodiesterase I from Bothrops atrox |
| Chemical Name Translation | 磷酸二酯酶I |
| PubChem Substance ID | 161498078 |
| InChI | InChI=1S/2C13H17N3S.3C12H15N3S/c1-16(2)10-4-3-8-7-12-11(6-9(8)5-10)15-13(14)17-12;1-16(2)10-4-3-8-6-11-12(7-9(8)5-10)17-13(14)15-11;1-15(2)9-3-7-5-10-11(6-8(7)4-9)16-12(13)14-10;1-15(2)8-5-7-3-4-10-11(9(7)6-8)14-12(13)16-10;1-15(2)8-5-7-3-4-10-11(9(7)6-8)16-12(13)14-10/h2*6-7,10H,3-5H2,1-2H3,(H2,14,15);5-6,9H,3-4H2,1-2H3,(H2,13,14);2*3-4,8H,5-6H2,1-2H3,(H2,13,14) |
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分类
- {SNA} 3.1.x.
- {SNA} 3.1.x.x Acting on esters, 3.x.x.x Hydrolases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, General Metabolic Enzymes, General Metabolic Enzymes I-Z,
- {SNA} 3.1.x.x Acting on esters, 3.x.x.x Hydrolases, Biochemicals and Reagents, Cyclic Nucleotide Metabolism, Enzyme Class Index,
产品应用
- Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP.
安全信息
GHS Symbol
- P233 Keep container tightly closed. ?保持容器密闭。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P302+P350
- P304+P340
- P342+P316
- P403 Store in a well-ventilated place. 储存在通风良好的地方。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H300+H310+H330
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 8,849,1967
其他信息
- Venom exonuclease (Phosphodiesterase I) successively hydrolyzes 5'-mononucleotides from 3'-OH-terminated ribo- and deoxyribo-oligonucleotides. The enzyme has an optimal pH range of 9.8-10.4 and a molecular weight of 115 kDa. Phosphodiesterase is inhibited by reducing agents such as glutathione, cysteine and ascorbic acids. It is completely inhibited by 5mM EDTA while ATP, ADP and AMP are partial inhibitors. The enzyme has an absolute requirement for Mg2+.
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