N1-(4-Methoxybenzyl)-N2,N2-Dimethyl-N1-(Pyrimidin-2-Yl)Ethane-1,2-Diamine 松齐拉敏
CAS 91-85-0 MFCD00865672
化学结构图
SMILES: COc1ccc(CN(CCN(C)C)c2ncccn2)cc1
化学属性
| Mol. Formula | C₁₆H₂₂N₄O |
|---|---|
| Mol. Weight | 286.37 |
| Boiling Point | - |
| Flash Point | - |
别名和识别编码
| Chemical Name | N1-(4-Methoxybenzyl)-N2,N2-Dimethyl-N1-(Pyrimidin-2-Yl)Ethane-1,2-Diamine |
|---|---|
| Chemical Name Translation | 松齐拉敏 |
| Wiswesser Line Notation | T6N CNJ BN1R DO1&2N1&1 |
| Synonym | 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)pyrimidine Ethylenediamine, N-(p-methoxybenzyl)-N',N'-dimethyl-N-2-pyrimidinyl- N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2-pyrimidyl)ethylenediamine NCI-C60708 Neohetramine Thonzylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {hazard_com} Tonzilamine |
| CAS Number | 91-85-0 |
| Beilstein Registry Number | 0284655 |
| LabNetwork Molecule ID | LN00200333 |
| PubChem Substance ID | 5457 |
| InChI | InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 |
| Canonical SMILES | - |
| MDL Number | - |
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相关文献及参考
- [2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.
- [1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127.
- [1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127.
- [2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 119 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 493 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 50 mg/kg SEX/DURATION : female 5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959
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