Chlorpropamide 1-(4-氯苯磺酰基)-3-丙脲

CAS 94-20-2 MFCD00079004

化学结构图

94-20-2
SMILES: CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1

化学属性

Mol. FormulaC10H13ClN2O3S
Mol. Weight277
TSCANo
Appearance 白色结晶性粉末。熔点127-129℃。易溶于氯仿和丙酮，略溶于乙醚、苯、在pH为6的水中溶解度为2.2mg/ml，在pH7.3的水中不溶。无臭，无味。
Melting Point127-130
SolubilityDMSO 55 mg/mL Water <1 mg/mL Ethanol 55 mg/mL

别名和识别编码

Chemical NameChlorpropamide
CAS Number94-20-2
Synonym NCI-C01752 N-Propyl-N'-(p-chlorobenzenesulfonyl)urea { 特泌胰 4-Chloro-N-[(propylamino)-carbonyl]benzenesulfonamide {hazar Diabeneza Chloronase Meldian Benzenesulfonamide, 4-chloro-N-[(propylamino)carbonyl]- ######## {Chemicalb 4-Chloro-4-((propylamino)carbonyl)benzenesulfonamide N-(p-Chlorobenzenesulfonyl)-N'-propylurea 1-p-Chlorophenyl-3-(propylsulfonyl)urea CHLOROPROPAMIDE N’-丙基-N’-对氯苯磺酰基脲 对氯苯磺酰丙脲 1-(p-Chlorobenzenesulfonyl)-3-propylurea 1-Propyl-3-(p-chlorobenzenesulfonyl)urea Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)- Mellinese 1-(4-CHLOROPHENYLSULFONYL)-3-PROPYLUREA Diabaril 1-[P-CHLOROBENZENESULFONYL]-3-PROPYLUREA 氯磺丙脲 1-((p-chloropenyl)sulfonyl)-3-propyl-ure Prodiaben P 607 {h 4-chloro-n-[(propylamino)carbonyl]benzenesulfonamide Glisema 4-chloro-n-[(propylamino)carbonyl]-benzenesulfonamid 4-chloro-n-((propylamino)carbonyl)-benzenesulfonamid Diabenese U-3818 N-Propyl-N'-p-chlorphenylsulfonylcarbamide Diabexan 1-(4-Chlorobenzenesulfonyl)-3-n-propylurea 1-(p-Chlorophen 4-Chloro-N-[(propylamino)carbonyl]benzene-sul-fonamide Diabinese CHLORPROPAMIDE Diabenal Adiaben 1-(4-Chlorophenylsulfonyl)-3-propylurea Diabet-pages 特泌胰;对氯苯磺酰丙脲;1-(4-氯苯磺酰基)-3-丙脲;N'-丙基-N'-对氯苯磺酰基脲 1- Diabetoral 1-((p-chlorophenyl)sulfonyl)-3-propyl-ure Chlorpropamide bioglumin Chloropropamide
MDL NumberMFCD00079004
PubChem Substance ID2727
EC Number202-314-5
Merck Number2186
Reaxys-RN2218363
Chemical Name Translation1-(4-氯苯磺酰基)-3-丙脲
Beilstein Registry Number2218363
Wiswesser Line NotationGR DSWMVM3
LabNetwork Molecule IDLN00196005
InChIInChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)
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分类

  • {SNA} Analytical S
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards,
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, C, CH, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, C, C-CH, CH, Cell Biology
  • Sulfur & Selenium Compounds
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • Pharmaceuticals
  • {SNA} Additional Standards,
  • {SNA} Analytical Stan

产品应用

  • ########

相关文献及参考

  • Turner, R.C. et al.: Diabetes, 27, 241 (1978); Grinnell, E.H. et al.: Am. J. Med. Sci., 253, 312 (1967); Taylor, J.A.: Clin. Pharmacol. Therap., 13, 710 (1972);

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H312 Harmful in contact with skin 皮肤接触有害
  • H312+H332
  • H303 May be harmfully swallowed 吞食可能有害
RTECSYS6650000
Signal word Warning
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 储存温度-20°C 
TYPE OF TEST            : TD

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSER

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 25 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - other hemolysis with or without anemia
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 18,981,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 409 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (3),36,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 83 mg/kg/25D-I
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from large intestine
   Liver - jaundice, cholestatic
REFERENCE :
   AJGAAR American Journal of Gastroenterology.  (American College of
   Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202)  V.21-
   1954-  Volume(issue)/page/year: 80,381,1985

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 177 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,349,1980

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 2 gm/L
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (96),55,1978

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2400 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 250 mg/L/30H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 56,215,1977

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 7100 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amste

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 166 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/pag

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 1358 mg/kg
SEX/DURATION            : female 1-26 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,187,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 884 mg/kg
SEX/DURATION            : female 1-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ADCHAK Archives of Disease in Childhood.  (British Medical Journal, POB
   560B, Kennebunkport, ME 04046)  V.1-    1926-  Volume(issue)/page/year:
   49,283,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   PROEAS Problemy Endokrinologii.  Problems of Endocrinology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-6, 1936-41; 13-    1967-
   Volume(issue)/page/year: 14,89,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 180 mg/kg
SEX/DURATION            : female 26-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive

其他信息

  • Sigma Aldrich:94-20-2(sigmaaldrich)
  • 上游原料:丁酰胺 --> 4-氯苯磺酰胺 --> 异氰酸丙酯
  • MOL 文件:94-20-2.mol
  • 图谱信息:氯磺丙脲(94-20-2)红外图谱(IR1) 氯磺丙脲(94-20-2)核磁图( 1 HNMR) 氯磺丙脲(94-20-2)核磁图( 13 CNMR) 氯磺丙脲(94-20-2)质谱(MS) 氯磺丙脲(94-20-2)红外图谱(IR2)
  • 氯磺丙脲价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1220 1-(4-氯苯磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea 500G 4600元 2014/06/02 C1220 1-(4-氯苯磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea 25G 623元
  • TCI Shanghai:1-(4-氯苯基磺酰基)-3-丙脲 1-(4-Chlorophenylsulfonyl)-3-propylurea,>;99.0%(T)(94-20-2)
  • 方法一:由对氯苯磺酰胺与丁酰胺反应而得对氯苯磺酰丙脲钠盐。再用盐酸酸化、精制而得成品。另一种方法是以对氯苯磺酰胺、异氰酸丙酯、三乙胺为原料。
  • 用途一:磺脲类口服降血糖药。作用强而持久，主要选择性地作用于胰岛-β-细胞，促进胰岛的分泌，使血糖降低。用于糖尿病。氯磺丙脲具有比较大的副作用，所以该药的使用量有逐年减少的趋势。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. C-CH - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CH - C

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