6-Hydroxymedroxyprogesterone acetate (6R,8R,9S,10R,13S,14S,17R)-17-乙酰基-6-羟基-6,10,13-三甲基-3-氧代-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊基[a]菲-17-乙酸酯 （甲羟孕酮杂质）

CAS 984-47-4 MFCD00984474

化学结构图

984-47-4
SMILES: CC(=O)O[C@]1(C(C)=O)CCC2[C@@H]3C[C@@](C)(O)C4=CC(=O)CC[C@]4(C)C3CC[C@@]21C

化学属性

Mol. Weight402.52
Mol. FormulaC24H34O5
Melting Point222-225 °C

别名和识别编码

CAS Number984-47-4
Chemical Name6-Hydroxymedroxyprogesterone acetate
Synonym (6R,8R,9S,10R,13S,14S,17R)-17-Acetyl-6-hydroxy-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (Medroxyprogesterone Acetate Impurity) {LY} (6R,8R,9S,10R,13S,14S,17R)-17-Acetyl-6-hydroxy-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (Medroxyprogesterone Acetate Impurity) {} {LY} (6R,8R,9S,10R,13S,14S,17R)-17-Acetyl-6-hydroxy-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (Medroxyprogesterone Acetate Impurity) {} {} {LY} (6R,8R,9S,10R,13S,14S,17R)-17-Acetyl-6-hydroxy-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (Medroxyprogesterone Acetate Impurity) {} {} {} {LY} (6R,8R,9S,10R,13S,14S,17R)-17-Acetyl-6-hydroxy-6,10,13-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]p
Chemical Name Translation(6R,8R,9S,10R,13S,14S,17R)-17-乙酰基-6-羟基-6,10,13-三甲基-3-氧代-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊基[a]菲-17-乙酸酯 （甲羟孕酮杂质）
PubChem Substance ID71749110
InChIInChI=1S/C24H34O5/c1-14(25)24(29-15(2)26)11-8-19-17-13-23(5,28)20-12-16(27)6-9-21(20,3)18(17)7-10-22(19,24)4/h12,17-19,28H,6-11,13H2,1-5H3/t17-,18+,19+,21-,22+,23-,24+/m1/s1
Canonical SMILESC[C@@]12[C@](CC[C@@]2(C(C)=O)OC(C)=O)([H])[C@@]3([H])[C@]([C@@]4(C([C@](O)(C3)C)=CC(CC4)=O)C)([H])CC1
MDL NumberMFCD00273296
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分类

  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids

产品应用

  • 6?-Hydroxy Medroxy Progesterone 17-Acetate is a major metabolite of Medroxyprogesterone 17-Acetate (M203560) as well as an impurity of Megestrol Acetate (M208050).

相关文献及参考

  • Chen, J. et al.: Chem. Pharnac. Bull., 57, 835 (2009); Zhang J.-W. et al.: Drug Metab. Dispos., 36, 2292 (2008); Fang, X.G. et al.: Acta Pharm. Sin., 21, 613 (1986);

安全信息

Hazard statements
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition

系列性分类

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