2-Amino-4-Nitrophenol 2-氨基-4-硝基苯酚

CAS 99-57-0 MFCD00007695

化学结构图

99-57-0
SMILES: Nc1cc([N+](=O)[O-])ccc1O

化学属性

Mol. FormulaC6H6N2O3
Mol. Weight154
Melting Point144.0 to 148.0 deg-C
Density1.511
TSCAYes
Flash Point100 ºC
Solubility略溶于水
RedoxOxidation

别名和识别编码

Chemical Name2-Amino-4-Nitrophenol
CAS Number99-57-0
Synonym 1-Amino-2-hydroxy-5-nitrobenzene 1-Hydroxy-2-amino-4-nitrobenzene 1-Nitro-3-amino-4-hydroxybenzene 1-amino-2-hydroxy-5-nitrobenzene 1-hydroxy-2-amino-4-nitrobenzene 2-AMINO-4-NITROPHENOL 2-Amino-4-nitro phenol 2-Amino-4-nitrofenol 2-Amino-4-nitrophenol 2-HYDROXY-5-NITROANILINE 2-Hydroxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID3613389
EC Number202-767-9
Beilstein Registry Number13(2)192
MDL NumberMFCD00007695
Reaxys-RN776533
Chemical Name Translation2-氨基-4-硝基苯酚
Wiswesser Line NotationZR BQ ENW
LabNetwork Molecule IDLN00008082
InChIInChI=1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
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分类

  • {SNA} Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; alcohol; 1fragment
  • Building Blocks, C6 to C8, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds, Phenols

产品应用

  • 作染料和医药的中间体。用于酸性媒性棕RH；中性黑BL、BRL、BGL等

相关文献及参考

  • Short: IV/4
  • Short: EINECS
  • Beilstein:13(2)192
  • Burnett, C. et al.: J. Toxicol. Env. Health, 2, 657 (1977); Burnett, C. et al.: Intt. J. Toxicol., 28, 217S (2009);

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H303 May be harmfully swallowed 吞食可能有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xi Xi,Xn
RTECSSJ6300000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
  • P302+P352+P332+P313+P362+P364
  • P305+
Signal word Warning
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S37 Wear suitable gloves 戴适当手套；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R36 Irritating to eyes 刺激眼睛
  • R22 Harmful if swallowed 吞咽有害
UN Number 2811
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 64375 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-339,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 246 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 2,657,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Skin and Appendages - hair
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 15,607,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GPOLA4 Genetica Polonica.  (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)
   V.1-    1960-  Volume(issue)/page/year: 26,109,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(8),50,1981

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MDMIAZ Medycyna Doswiadczalna i Mikrobiologia.  For English translation, see
   EXMMAV.  (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)  V.1-    1949-
   Volume(issue)/page/year: 31,11,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 ug/plate
REFERENCE :
   CMMUAO Chemical Mutagens.  Principles and Methods for Their Detection.
   (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  V.1-    1971-
   Volume(issue)/page/year: 8,151,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,2423,1975

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 5 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-339,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 249 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-339,1988

Restrict 危险品

其他信息

  • 上游原料:硫磺 --> 硫化钠 --> 九水硫化钠 --> 2,4-二硝基氯苯 --> 多硫化钠
  • 刺激数据:眼睛-兔子 100 毫克/24小时 中度
  • 毒性分级:中毒
  • 用途一:用作染料及医药中间体
  • Hazard Note:Irritant
  • 灭火剂:二氧化碳、砂土、泡沫、干粉
  • MSDS 信息:邻氨基对硝基苯酚(99-57-0).msds
  • 类别:有毒物品
  • MOL 文件:99-57-0.mol
  • Sigma Aldrich:99-57-0(sigmaaldrich)
  • 下游产品:6-硝基-2H-1 4-苯并恶嗪-3(4H)-酮 --> 中性黑 BL --> 酸性媒介棕 RH --> 溶剂红KL --> 活性灰K-B4RP --> 中性棕Rl --> 活性黑8 --> 皮革喷涂红GL --> 皮革喷涂黑RL --> 皮革喷涂黄GL
  • 用途三:作染料和医药的中间体。用于酸性媒性棕RH；中性黑BL、BRL、BGL等。
  • TCI Shanghai:2-氨基-4-硝基苯酚 2-Amino-4-nitrophenol,>;98.0%(T)(99-57-0)
  • 外观性质:橙黄色结晶。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • Alfa Aesar:2-氨基-4-硝基苯酚,98% 2-Amino-4-nitrophenol, 98%(99-57-0)
  • 检测方法:HPLC
  • 急性毒性:口服-大鼠 LD50: 2400 毫克/公斤; 口服-小鼠 LD50: 850 毫克/公斤
  • 2-氨基-4-硝基苯酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0378 2-氨基-4-硝基苯酚 2-Amino-4-nitrophenol 25G 360元 2014/06/02 A0378 2-氨基-4-硝基苯酚 2-Amino-4-nitrophenol 500G 3070元 2010/06/21 400890250 2-氨基-4-硝基苯酚 2-Amino-4-nitrophenol 99% 25 GR 1202元
  • 用途四:作染料和医药的中间体。用于酸性媒性棕RH；中性黑BL、BRL、BGL等
  • 能溶于酸、醇乙醚，稍溶于水
  • 用途二:用于制造活性染料、酸性染料、中性染料及溶剂染料等
  • 可燃性危险特性:明火可燃; 受热分解有毒氮氧化物气体
  • 图谱信息:2-氨基-4-硝基苯酚(99-57-0)红外图谱(IR2) 2-氨基-4-硝基苯酚(99-57-0)红外图谱(IR1) 2-氨基-4-硝基苯酚(99-57-0)红外图谱(IR3) 2-氨基-4-硝基苯酚(99-57-0)质谱(MS)
  • Acros Organics:2-氨基-4-硝基苯酚 2-Amino-4-nitrophenol, 99%(99-57-0)
  • 方法一:由2,4-二硝基氯苯水解，用多硫化钠部分还原的方法制得。原料消耗定额：2,4-二硝基氯苯（工业品）2100kg/t、液碱（40%）2050kg/t、多硫化钠（100%）700kg/t、盐酸（37%）150kg/t。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  6. C6 to C8 - Phenols
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Protected Alcohols/Phenols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers

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