VEGFR

下级目录

Henatinib

FIIN-1

AAL-993

AEE 788

Foretinib

CEP-11981

AZD-2932

Golvatinib

3-[(4-BROMO-2,6-DIFLUOROPHENYL)METHOXY]-5-[[[[4-(1-PYRROLIDINYL)BUTYL]AMINO]CARBONYL]AMINO]-4-ISOTHIAZOLECARBOXAMIDE

Axitinib

1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-

Bms-690514

目录项下的产品

1239269-51-2 / MFCD339269512
Henatinib maleate is t he maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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试剂

1256152-35-8 / MFCD356152358
FIIN-1

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269390-77-4 / MFCD69390774
AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

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497839-62-0 / MFCD97839620
{6-[4-(4-Ethylpiperazin-1-Ylmethyl)-Phenyl]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}-((R)-1-Phenylethyl)Amine
{6-[4-(4-乙基哌嗪-1-基甲基)-苯基]-7H吡咯并[2,3-d]嘧啶-4-基}-((R)-1-苯基乙基)胺

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849217-64-7 / MFCD49217647
N-(3-Fluoro-4-((6-Methoxy-7-(3-Morpholinopropoxy)Quinolin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide
N-(3-氟-4-((-甲氧基-7-(3-吗啉代丙氧基)喹啉-4-基)氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二甲酰胺

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试剂

856691-93-5 / MFCD56691935
CEP-11981

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883986-34-3 / MFCD83986343
2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
2-(4-((6,7-二甲氧基喹唑啉-4-基)氧基)苯基)-N-(1-异丙基-1H-吡唑-4-基)乙酰胺

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928037-13-2 / MFCD028037132
N-(2-Fluoro-4-((2-(4-(4-Methylpiperazin-1-Yl)Piperidine-1-Carboxamido)Pyridin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide
N-[2-氟-4-[[2-[[[4-(4-甲基哌嗪-1-基)哌啶-1-基]羰基]氨基]吡啶-4-基]氧基]苯基]-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺

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252003-65-9 / MFCD07772279
CP-547632, also known as PAN-90806, is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor , and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies.

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319460-85-0 / MFCD09837898
Axitinib
阿西替尼

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中华人民共和国
√

702675-74-9 / MFCD12546134
BX795, 98%, a potent and selective dual inhibitor of TBK1/PDK1
N-[3-[[5-碘-4-[[3-[(2-噻吩基羰基)氨基]丙基]氨基]-2-嘧啶基]氨基]苯基]-1-吡咯烷甲酰胺

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试剂

中华人民共和国
上海市

859853-30-8 / MFCD18633295
Bms-690514
BMS-690514

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VEGFR

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