Calcium Channel

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CARBOXYAMIDOTRIAZOLEOROTATE

TETRANDRINE

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187739-60-2

187739-60-2 / MFCD87739602
Carboxyamidotriazole orotate (CTO) is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis.

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518-34-3

518-34-3 / MFCD00082551
(S,S)-(+)-Tetrandrine
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中华人民共和国
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