Farnesyl transferase - D to K

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180977-34-8

180977-34-8 / MFCD80977348
FTI 277 HYDROCHLORIDE

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170006-72-1

170006-72-1 / MFCD06409253
FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene.

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170006-73-2

170006-73-2 / MFCD06795840
FTI-277 trifluoroacetate salt

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